Synthesis of novel [3,1]-benzothiazepine and [3,1]-benzoxazepine derivatives with antitumoral activity

Abstract

benzoxazepines from the reaction of C-allylanilines and isothiocyanates or isocyanates without the need for the isolation of any intermediate is described. The compounds were obtained in good to moderate yields and some exhibited cytotoxic activity against tumor cell lines. Scheme 1 Synthesis of N-allylanilines 2a-d. Scheme 2 Synthesis of C-allylanilines 3a-d.

Synthesis, Antibacterial Activity, and Structure–Activity Relationship of Fusaric Acid Analogs

“…FA analogs 17 and 18 were synthesized via the Williamson ether synthesis of 15 and 16 with alkyl/aromatic halide followed by sodium hydroxide mediated hydrolysis (Scheme 3). 22 Compounds 20–22 were obtained from 19 by an alkylation or amidation (Scheme 4) with alkyl halide, acyl chloride, or sulfonyl chloride 23–25 …”