Synthesis of novel block copolymers containing polyamide4 segments and control of their biodegradability

Hashimoto, Kazuhiko; Sudo, Mie; Sugimura, Takayuki; Inagaki, Yoshiki

doi:10.1002/app.20348

Cited by 26 publications

(10 citation statements)

References 24 publications

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“…And most of the research publications discussed the significant role of natural polymers, chitosan and collagen in biomedical applications [1][2][3][4]. For chitosan based material, de-acetylated chitosan was in use, and for collagen based materials, type-I collagen of bovine, porcine and fish were in use.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of malonic acid cross-linked chitosan and collagen 3D scaffolds: an approach on non-covalent interactions

Mitra

Sailakshmi

Gnanamani

et al. 2012

J Mater Sci: Mater Med

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The present study emphasizes the influence of non-covalent interactions on the mechanical and thermal properties of the scaffolds of chitosan/collagen origin. Malonic acid (MA), a bifuncitonal diacid was chosen to offer non-covalent cross-linking. Three dimensional scaffolds was prepared using chitosan at 1.0% (w/v) and MA at 0.2% (w/v), similarly collagen 0.5% (w/v) and MA 0.2% (w/v) and characterized. Results on FT-IR, TGA, DSC, SEM and mechanical properties (tensile strength, stiffness, Young's modulus, etc.) assessment demonstrated the existence of non-covalent interaction between MA and chitosan/collagen, which offered flexibility and high strength to the scaffolds suitable for tissue engineering research. Studies using NIH 3T3 fibroblast cells suggested biocompatibility nature of the scaffolds. Docking simulation study further supports the intermolecular hydrogen bonding interactions between MA and chitosan/collagen.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of malonic acid cross-linked chitosan and collagen 3D scaffolds: an approach on non-covalent interactions

Mitra

Sailakshmi

Gnanamani

et al. 2012

J Mater Sci: Mater Med

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“…Most of the research publications discusses the significance of chitosan and collagen in biomedical applications [1][2][3] . Collagen is known to be the most promising material and with diverse applications in tissue engineering for its excellent biocompatibility and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

Studies on Cross-linking of succinic acid with chitosan/collagen

et al. 2013

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The present study summarizes the cross-linking property of succinic acid with chitosan /collagen. In detail, the chemistry behind the cross-linking and the improvement in mechanical and thermal properties of the cross-linked material were discussed with suitable instruments and bioinformatics tools. The concentration of succinic acid with reference to the chosen polymers was optimized. A 3D scaffold prepared using an optimized concentration of succinic acid (0.2% (w/v)) with chitosan (1.0% (w/v)) and similarly with collagen (0.5% (w/v)), was subjected to surface morphology, FT-IR analysis, tensile strength assessment, thermal stability and biocompatibility. Results revealed, cross-linking with succinic acid impart appreciable mechanical strength to the scaffold material. In silico analysis suggested the prevalence of non-covalent interactions, which played a crucial role in improving the mechanical and thermal properties of the cross-linked scaffold. The resultant 3D scaffold may find application as wound dressing material, as an implant in clinical applications and as a tissue engineering material.

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“…Recent research on biomaterial development suggests that biopolymers of natural origin find immense clinical applications. Most of the research publications discussed the significant role of natural polymers, chitosan, and collagen in biomedical applications 1–4…”

Section: Introductionmentioning

confidence: 99%

Adipic acid interaction enhances the mechanical and thermal stability of natural polymers

Mitra

Sailakshmi

Gnanamani

et al. 2012

J of Applied Polymer Sci

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Application of biopolymers for biomedical applications limits with the functional and structural properties of the materials. Crosslinkers are used to provide the requisite properties. The question on biocompatibility of the existing crosslinkers necessitates the need for alternative crosslinkers. In the present study, adipic acid was chosen as crosslinker and evaluated the mode of interaction with chitosan and type‐I collagen. A 3D scaffold biopolymer material was prepared using chitosan at 1.0% (w/v) and adipic acid at 0.2% (w/v), similarly collagen 0.5% (w/v) and adipic acid 0.2% (w/v) displayed an improved mechanical strength and in addition found biocompatible for NIH 3T3 fibroblast cells. The chemistry behind the interaction and the characteristics of the biopolymer material obtained upon crosslinking suggests that noncovalent interactions play the major role in deciding the property of the said materials and their suitability for biomedical applications. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

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Synthesis of novel block copolymers containing polyamide4 segments and control of their biodegradability

Cited by 26 publications

References 24 publications

Preparation and characterization of malonic acid cross-linked chitosan and collagen 3D scaffolds: an approach on non-covalent interactions

Preparation and characterization of malonic acid cross-linked chitosan and collagen 3D scaffolds: an approach on non-covalent interactions

Studies on Cross-linking of succinic acid with chitosan/collagen

Adipic acid interaction enhances the mechanical and thermal stability of natural polymers

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