Synthesis of novel chiral metal complexes derived from chiral thiosemicarbazide ligands as potential antioxidant agents

Başaran, Eyüp; Sıcak, Yusuf; Soğukömeroğulları, Hatice Gamze; Karaküçük‐İyidoğan, Ayşegül; Oruç‐Emre, Emine Elçin; Sönmez, Mehmet

doi:10.1002/chir.23069

Cited by 14 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The NH (H-6, H-7, and H-9) protons of thiosemicarbazide (-NH-NH-C=S-NH-) derivatives 1-12 were detected at δ 9.11-10.03, 10.34-11.29, and 9.55-10.52 ppm, respectively. In the a study [25], 1 H NMR protons data in the thiosemicarbazide scaffold were found to be compatible with the chemical shift values of thiosemicarbazide protons in this study. The resonance of proton H-7 in the 1,2,4-triazole derivatives at 13.97-14.22 ppm and the disappearance of the H-6 and H-9 protons in the thiosemicarbazide derivatives in the cyclization products were de nite evidence of the synthesis of 1,2,4-triazole derivatives.…”

Section: Chemistrysupporting

confidence: 86%

Design and antiproliferative and antioxidant activities of furan-based thiosemicarbazides and 1,2,4-triazoles: their structure-activity relationship and SwissADME predictions

Sıcak

2021

Med Chem Res

Self Cite

View full text Add to dashboard Cite

Due to the limited number of drugs in current clinical use, the diverse biological applications of furan have encouraged the preparation of a wide variety of thiosemicarbazide and triazole derivatives for the purpose of developing new drug agents. In this study aimed to investigate the antiproliferative and antioxidant activities of some thiosemicarbazides (1-12) and 1,2,4-triazoles (13-24). Compound 15 (IC 50 : 8.81±0.28 µM) showed the highest antiproliferative activity against the cervical (HeLa) cancer cell line among the compounds. Compounds 15, 20, 21, and 22 of the 1,2,4-triazole derivatives (13-24) exhibited excellent antioxidant activity. Moreover, the physicochemical properties, pharmacokinetic properties, drug similarity, and medicinal chemistry properties of all synthesized products were calculated using SwissADME. In addition, the effect of the structure-activity relationships of the 1,2,4-triazole derivatives (13-24) on the results of antiproliferative and antioxidant activity assays was evaluated.

show abstract

Section: Chemistrysupporting

confidence: 86%

Design and antiproliferative and antioxidant activities of furan-based thiosemicarbazides and 1,2,4-triazoles: their structure-activity relationship and SwissADME predictions

Sıcak

2021

Med Chem Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…DPPH free radical scavenging and ABTS cation radical scavenging assays were conducted as described by Ferreira et al (2014). The procedure defined by Başaran et al (2019) was used to determine the β-Carotene-linoleic acid and cupric reducing antioxidant capacity (CUPRAC) of films with some adjustments. Solutions of films were prepared at 50, 25, 12.5 and 6.25 ppm concentrations.…”

Section: Determination Of Antioxidant Activitymentioning

confidence: 99%

Citrus Limon L. Peel Powder Incorporated Polyvinyl Alcohol/Corn Starch Antioxidant Active Films

Terzioğlu

Sıcak

2021

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

View full text Add to dashboard Cite

Active food packaging films has gain more significance over conventional packaging. In this study, novel active composite films were prepared by incorporating lemon peel to a polyvinyl alcohol-starch matrix. The morphological, thermal and antioxidant activity evaluation of polyvinyl alcohol-starch-lemon peel composite films were discussed to determine whether the presence and content of lemon peel influenced the film's characteristics. The results indicated that tested properties of composite films depended on the content of lemon peel. It was found that the thermal stability and antioxidant activity of films considerably improved upon the incorporation of peel. The prepared films with enhanced antioxidant activity may be used for preservation of oxidation-sensitive food products. The results showed that lemon by-product has great potential to be evaluated into added-value products for functional packaging applications. The developed packaging films will be new alternatives for food preservation materials.

show abstract

“…Thus, the sulfur atom can bind to the metal in its thione form or in its thiolate form [29][30][31]. There are also complexes in which the sulfur atom remains uncoordinated [32,33]. In this article, we report the synthesis and structural characterization of the Co(II/III), Ni(II) and Zn(II) complexes of 1-(1-hydroxypropan-2-ylidene)thiosemicarbazide (H2L) (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Crystal structures of bis[1-(1-hydroxypropan-2-ylidene)thiosemicarbazide-κ3S,N,O)cobalt(III)-tetra(thiocyanato-κN) cobalt(II) methanol solvate, bis{1-(1-hydroxypropan-2-ylidene)thiosemicarbazide-κ3S,N,O}nickel(II) bis(thiocyanate) and (1-(1-hydroxypropan-2-ylidene)thiosemicarbazide-κ3S,N,O)bis(thiocyanato-κN)zinc(II)

et al. 2022

View full text Add to dashboard Cite

The reactions of Schiff base 1-(1-hydroxypropan-2-ylidene)thiosemicarbazide (H2L), with salt of thiocyanate metal (II) (Co, Ni, or Zn), provided one dinuclear and two new mononuclear complexes, formulated respectively as {[Co(LH)2]2·[Co(NCS)4] ·2(MeOH)} (1), {[Ni(H2L)2]·[(NCS)2]} (2) and [Zn(H2L)(NCS)2] (3). These compounds have been studied and characterized by elemental analysis, infrared, and ultraviolet-visible (UV-vis) spectroscopies. The structures of the three complexes have been resolved by X-ray crystallography technique. The dinuclear complex 1 crystallizes in the orthorhombic space group Fdd2 with the following unit cell parameters a = 33.1524 (3) Å, b = 19.3780 (2) Å, c = 13.2533 (2) Å, V = 8514.28 (17) Å3, Z = 16, R1 = 0.025 and wR2 = 0.063, the mononuclear complex 2 crystallizes in the monoclinic space group P21/n with the following unit cell parameters a = 11.5752 (1) Å, b = 12.3253 (1) Å, c = 14.2257 (2) Å, β = 106.855 (1)°, V = 1942 (4) Å3, Z = 4, R1 = 0.038 and wR2 = 0.106 and the mononuclear complex 3 crystallizes in the monoclinic space group P21/c with the following unit cell parameters a = 6.1121 (2) Å, b = 26.8272 (7) Å, c = 8.0292 (2) Å, β = 99.876 (3)°, V = 1297.04 (6) Å3, Z = 4, R1 = 0.026 and wR2 = 0.057. The asymmetric unit of Complex 1 contains one cationic unit in which the ligand acts in its monodeprotonated form in tridentate fashion and one half of the anionic unit containing two thiocyanate co-ligands. In complexes 2 and 3, the ligand acts in its neutral form in a tridentate manner. In complex 2, two ligand molecules coordinate the Ni(II) center, and the thiocyanate moieties remains uncoordinated. In complex 3, the Zn(II) is coordinated by one ligand molecule and two thiocyanate groups through their nitrogen atoms. Numerous hydrogen bonds consolidated the structures of complexes 1, 2, and 3 in a three-dimensional network.

show abstract

Synthesis of novel chiral metal complexes derived from chiral thiosemicarbazide ligands as potential antioxidant agents

Cited by 14 publications

References 28 publications

Design and antiproliferative and antioxidant activities of furan-based thiosemicarbazides and 1,2,4-triazoles: their structure-activity relationship and SwissADME predictions

Design and antiproliferative and antioxidant activities of furan-based thiosemicarbazides and 1,2,4-triazoles: their structure-activity relationship and SwissADME predictions

Citrus Limon L. Peel Powder Incorporated Polyvinyl Alcohol/Corn Starch Antioxidant Active Films

Contact Info

Product

Resources

About