2003
DOI: 10.1016/s0040-4020(03)00211-4
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Synthesis of novel exocyclic amino nucleosides by parallel solid-phase combinatorial strategy

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Cited by 31 publications
(14 citation statements)
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References 49 publications
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“…These observations confirm the need to develop clitocine analogues as potential anticancer agents [17][18][19] to improve this index.…”
supporting
confidence: 75%
“…These observations confirm the need to develop clitocine analogues as potential anticancer agents [17][18][19] to improve this index.…”
supporting
confidence: 75%
“…Recently, a solid-phase parallel synthesis was developed for the construction of a nucleoside library (Scheme 22.5) [11]. The anchoring of 26 to polystyrene monomethoxytrityl chloride (MTT-Cl) resin provided the key intermediate (27), the azide group of which was reduced and subsequently condensed with 4,6-dichloro-5-nitropyrimidine (3) to yield 29.…”
Section: Biological Activitymentioning
confidence: 99%
“…Using selected QSAR models, one can calculate average activities of the compounds from the test set, which smoothes inaccuracies of particular models, thus improving the robustness of predictions. During the training stage, An and colleagues reported a versatile parallel solid-phase combinatorial strategy for the synthesis of a large nucleosides library [32]. Twelve libraries (L1-12) of 1152 novel exocyclic triazynylamino nucleosides and one library (L13) TRIAL has selected three best fit models for each family of studied anti-HIV compounds and then applied them for test calculations.…”
Section: Non-nucleoside Reverse Transcriptase Inhibitors (Nnrtis)mentioning
confidence: 99%