Synthesis of novel functionalized 5-nitroisoquinolines and evaluation of in vitro antimalarial activity

Synthesis, structure analysis, anti-bacterial and in vitro anti-cancer activity of new Schiff base and its copper complex derived from sulfamethoxazole

“…Absorbance spectra were recorded on a SHIMADZU spectrophotometer in the range of 300-1000nm. 1 H and 672 I Rama and R Selvameena 13 CNMR spectra of ligand was recorded with a Bruker Spectrospin Avance DPX-400 using TMS as internal standard and DMSO-d 6 as solvent. Magnetic susceptibility measurement was carried out on solid complex using Gouy balance at room temperature.…”

“…Interest in these ligands has been driven, in part, due to potential beneficial biological activity of the ligands and their metal complexes, including anti-malarial, 1 anti-bacterial, 2 anti-fungal, 3 anti-viral activity, 4 and an excellent lead for the development of anti-tubercular agent. 5 Biological activities of metal complexes differ from those of either ligands or the metal ions and increased and/or decreased biological activities have been reported for several metal complexes, like Pd(II).…”

Novel imidazo[2,1-b]-1,3,4-thiadiazoles as promising antifungal agents against clinical isolate of Cryptococcus neoformans

“…Moreover, integration of 5-nitroisoquinolines (IX) and Abacavir prodrugs (X) with Schiff bases enhanced the anti-malarial and anti-HIV scope of these compounds [29,30]. Equally, integrating isoniazid a well-known anti-TB drug with aryl M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 5 hydrzone led to a hybrid (XI) which exhibited potent anti-tubercular activity [31].…”

A class of novel N-(3S-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-l-amino acid derivatives: their synthesis, anti-thrombotic activity evaluation, and 3D QSAR analysis

“…Besides a number of bioactivities [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31], tetrahydroisoquinolines were identified as anti-platelet aggregation agents. The investigations of the anti-platelet aggregation mechanism of tetrahydroisoquinolines indicated that in addition to receptor and b-adrenergic/a 2 -adrenergic receptor system [32], thromboxane A 2 /prostaglandin H 2 receptor system was commonly involved, for instance they may exert their inhibitory effects on AA-induced platelet aggregation partly by inhibiting the production of TXA2 from AA and partly by directly blocking the TXA2 receptor [33][34][35].…”