Synthesis of novel imidazo[1,2-$a$]pyridines and evaluation of their antifungal activities

Abstract

3) and evaluated for antifungal activity against Microsporum gypseum NCPF 580, M. canis, Trichophyton tonsurans NCPF 245, T. rubrum, Candida albicans ATCC 10231, and C. parapsilosis ATCC 22019 using amphotericin B as the standard. The chemical structures of the compounds were confirmed by elemental analysis, IR, 1 H NMR, 13 C NMR, HMBC ( 13 C, 1 H), and mass spectra. Most of the tested compounds showed moderate antifungal activity. Hydrazinecarbothioamide derivatives 4h and 4f exhibited the highest activity against M. canis (MIC: 2 µ g mL −1 and 4 µ g mL −1 , respectively).

2-Hydroxy-1-((2-(pyridin-2-yl)hydrazono)methyl)tryptanthrin as a Fluorescent Chemosensor for Metal Ions

“…The synthesis of 1-formyl-2-hydroxytyuptanthrin (T2OH1CHO) was performed using the Duff reaction [8]. The synthesis of T2OH1CH=N-NH-Pyri was performed according to a previously reported method [9] with some slight modifications.…”

5-(5-Chloro-2-hydroxybenzoyl)-1-methyl-3-nitropyridin-2(1H)-one

“…Compounds that contain pyridine and its derivatives have occupied a central role in the development of coordination chemistry and biochemistry (Rajeswar et al, 2014). Heterocycles are important molecular building blocks that are involved in the structural composition of crucial chemicals for humans, including pharmaceuticals, natural resources, veterinary, agricultural products, analytical reagents and dyes (Gö ktaş et al, 2014). In drug discovery, pyridine has been used as a bioisosteric replacement of the benzene ring (Ajit Kumar et al, 2011).…”

A Review on Synthesis, Lanthanide Complexes and Biological Activites of Hydrazone Derivatives of Hydrazinecarbothioamides

“…The antifungal properties of the hydrazine carbothioamides were investigated with C. albicans and C. parapsilosis for 48 hrs. the compounds showed activity against the organisms[14].…”