Synthesis of novel naphthalimide tethered 1,2,3-triazoles: In vitro biological evaluation and docking study of anti-inflammatory inhibitors

An Overview of the Biological Evaluation of Selected Nitrogen-Containing Heterocycle Medicinal Chemistry Compounds

“…Bengam et al [ 38 ] designed and synthesized novel naphthalimide-1,2,3-triazole tethered heterocycles and evaluated their in vitro anti-inflammatory properties. Among the compounds tested, 32 displayed inhibitions comparable to the reference compound (diclofenac sodium).…”

“…Among the evaluated compounds, N-benzyl-6-((1-(2nitrophenyl)-1H-1,2,3-triazol-4-yl)methoxy)quinazolin-4-amine 31 was shown to have the highest inhibitory activity with an IC 50 value of 0.23 µM (see Figure 7). Bengam et al [38] designed and synthesized novel naphthalimide-1,2,3-triazole tethered heterocycles and evaluated their in vitro anti-inflammatory properties. Among the compounds tested, 32 displayed inhibitions comparable to the reference compound (di-clofenac sodium).…”

Synthesis, Reactions, and Antimicrobial Evaluation of 2-(1,3-dioxoisoindolin-2-yl)acetohydrazide derivatives

“…Experimental). Azide derivative 9 reacted with thioglycolic acid in dry benzene under refluxing to afford new 3-((1,3dioxoisoindolin-2-yl)methyl)thiazolidine-2,4-dione (15). In the same manner, 3-oxobenzo[d]isothiazol-2(3H)-yl 16 and 3-oxo-1,3-dihydro-2H-indazol-2-yl 17 derivatives had been obtained via reaction of azide 9 with thiosalicylic acid and anthranilic acid, respectively under the same conditions (Scheme 4).…”

“…Furthermore, hybrid of thiadiazole-phthalimide and triazole-phthalimide moieties have afforded remarkable cytotoxic effects. [14][15][16] Heterocyclic compounds that have five and six membered ring are considered as a pivotal scaffold of targeted drugs in pharmaceutical and medicinal chemistry, this is a results of their resemblance with many biologically efficient compounds in our body. Also, they provide many medicinal and biological applications such as antimicrobial, anticonvulsant, antibacterial, anticancer, anti-inflammatory and antifungal effects.…”

Design, synthesis and biological activities of 1,2,4‐triazolo[1,5‐a]pyrimidine‐7‐amine derivatives bearing 1,2,4‐oxadiazole motif

“…[ 10 ] Some of pyrimidinamine compounds had been commercialized as pesticides, such as the fungicides Ethirimol and Bupirimate, the insecticide Dicyclanil, and the herbicide Nicosulfuron. Triazole is another nitrogen‐linked heterocycle, which also possessed excellent activity, such as fungicidal, [ 11–13 ] herbicidal, [ 14 ] antiinflammatory, [ 15 ] antimicrobial, [ 16 ] antiviral, [ 17 ] and antioxidant [ 18 ] activities. Fused heterocycles often exhibited two heterocycles' properties.…”