Synthesis of Novel Pyrazole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity

Abstract

To discover new compounds with favorable herbicidal activity, a range of phenylpyridine moiety-containing pyrazole derivatives were designed, synthesized, and identified via NMR and HRMS. Their herbicidal activities against six species of weeds were evaluated in a greenhouse via both pre- and post-emergence treatments at 150 g a.i./hm2. The bioassay revealed that a few compounds exhibited moderate herbicidal activities against Digitaria sanguinalis, Abutilon theophrasti, and Setaria viridis in post-emergence treatment. For instance, compounds 6a and 6c demonstrated 50% inhibition activity against Setaria viridis, which was slightly superior to pyroxasulfone. Thus, compounds 6a and 6c may serve as the new possible leading compounds for the discovery of post-emergence herbicides.

Synthesis and Biological Activity of Myricetin Derivatives Containing Pyrazole Piperazine Amide

“…Pyrazoles are a class of nitrogen-containing five-membered heterocyclic compounds with a wide range of insecticidal [ 27 , 28 ], fungicidal [ 29 , 30 ] and herbicidal [ 31 ] activities. pyrazole-4-carbonyl compounds have exhibited good fungicidal activities, making them a hot structure in the research and development of agricultural fungicides [ 32 ].…”