Synthesis of novel pyrido[2,1-b]benzothiazole and N-substituted 2-pyridylbenzothiazole derivatives showing remarkable fluorescence and biological activities

Synthesis and photobiological applications of naphthalimide–benzothiazole conjugates: cytotoxicity and topoisomerase IIα inhibition

“…A series of conjugates with three biological active pharmacophores of naphthalimide, benzothiazole, and indole substituted with different aliphatic and aromatic amines (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) has been synthesized in moderate to good yields. Compounds 7-22 were tested for their cytotoxicity against A549 (lung), MCF7 (breast), and HeLa (cervix) human cancer cells that showed cytotoxicity in the range of IC 50 values of 0.14-8.59 mM, indicated that compounds showed excellent activity towards these cancer cell lines.…”

“…7,8 Naphthalimide, a heterocyclic moiety, is a group of wellestablished antiproliferative agents, and some derivatives (amonade, mitonade, and UNBS5162) have reached different phases of clinical trials. 9,10 Another heterocyclic moiety, benzothiazole-based compounds, were also reported to show extensive activities towards various biological agents [11][12][13] in which this moiety exhibited excellent anticancer activity. [14][15][16] Previously, various hybrids of benzimidazole and naphthalimide moieties, 17 combined without any linker, have been synthesized and were evaluated for their anticancer activities.…”

Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

“…Benzothiazole substituted derivatives were prepared and tested for their antimicrobial potentials. [36] The compound 57 was active against E. coli, compound 58 was found more effective against S. mulans and C. albicans. The efficiency of compound 58 and 59 against C. albicans was the same under identical in vitro experimental conditions.…”

Crystal structure of 2-{[5-amino-1-(phenylsulfonyl)-1H-pyrazol-3-yl]oxy}-1-(4-methylphenyl)ethan-1-one

“…We are interested in devising synthetic strategies for heterocyclic ring systems containing the N-sulfonyl-and N-sulfonylamino moiety, which have shown significant biological activity as novel antiviral and antimicrobial agents (Azzam et al, 2017(Azzam et al, , 2020Elgemeie et al, 2017Elgemeie et al, , 2019Zhu et al, 2013). In addition, some of our recently published N-arylsulfonylpyrazoles (Elgemeie & Hanfy, 1999;Elgemeie et al, 1998Elgemeie et al, , 2002Elgemeie et al, , 2013 have been shown to be active as inhibitors of cathepsin B16 enzyme and NS2B-NS3 virus (Sidique et al, 2009;Myers et al, 2007).…”