Synthesis of novel quaternary ammonium salts from 1, 2-benzothiazine derivatives

Gul, Salman; Saleem, Mahmood; Munawar, Munawar Ali; Ahmad, Hafiz Adnan; Ahmed, Ejaz; Begum, Robina; Farooqi, Zahoor H.

doi:10.1080/17415993.2020.1797743

Cited by 2 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to previous studies, 40 quaternary ammonium cationic groups can interact electrostatically with negatively charged proteins and lipids located on the surface of bacteria, causing them to be inactivated and damaged. More specifically, quaternary ammonium groups were found to interact electrostatically with oppositely charged components of bacterial cell membranes, disrupting their structure and altering their permeability so that bacteria could not properly achieve material information exchange with the outside world, thereby inhibiting their growth or even killing them.…”

Section: Growth Of L929mentioning

confidence: 99%

Cross-Linked Collagen-Based Scaffold: Anti-infective Potential, Hydrophilic, and Biocompatible

Liu

Zheng

Feng

et al. 2022

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

Porcine decellularized dermal matrix (pADM) was a type of collagen-based medical scaffold material with excellent biological properties. Because of the lack of antibacterial properties, the wound infection caused by bacteria during the treatment process greatly affected the recovery and even the life safety of patients. In this paper, a creative design idea of antimicrobial material was proposed based on free radical polymerization reaction. The amphoteric monomer sulfobetaine methacrylate (SBMA) was employed to cross-link with methacrylated pADM (MA-pADM) by free radical polymerization to obtain cross-linked pADM grafted with amphoteric ions (C-MA-SBMA-pADM). The collagen scaffold after cross-linking had sufficient collagen stability, proper mechanical properties, and retained the natural structure of collagen while introducing hydrophilic sulfonic acid groups and quaternary ammonium groups, and C-MA-SBMA-pADM exhibited excellent hydrophilic properties by water contact angle detection. The results of cellular experiments showed that the scaffold had good cytocompatibility. Escherichia coli and Staphylococcus aureus were used to test the antibacterial properties of the material, and the results showed that the cross-linked C-MA-SBMA-pADM had good antibacterial effects. In conclusion, a cross-linked collagen-based scaffold was prepared with good mechanical properties, cytocompatibility, and also excellent antibacterial properties, which was expected to be more widely used in the field of tissue engineering scaffold materials.

show abstract

Section: Growth Of L929mentioning

confidence: 99%