Synthesis of novel Schiff’s bases of highly potential biological activities and their structure investigation

Zayed, Ehab M.; Zayed, M.A.

doi:10.1016/j.saa.2015.02.024

Cited by 62 publications

(59 citation statements)

References 32 publications

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“…This d−d transition band strongly favors a distorted octahedral geometry around the metal ion. This geometry is further supported by its magnetic susceptibility value (1.5 BM) [25,26,27].…”

Section: Magnetic Susceptibility and Electronic Spectral Studiesmentioning

confidence: 56%

“…These bands correspond to 3A2g (F)→3T2g (F), 3A2g (F)→3T1g (F), and 3A2g (F)→3T1g (P) transitions, respectively, being characteristic of an octahedral geometry. This geometry is further supported by its magnetic susceptibility value (2.4 BM) [25,26,27].…”

Section: Magnetic Susceptibility and Electronic Spectral Studiesmentioning

confidence: 56%

“…The spectrum shows also a band at 27,777 cm −1 which may be attributed to ligand to metal charge transfer. This geometry is further supported by its magnetic susceptibility value (3.8 BM) [25,26,27]. The diffused reflectance spectrum of the Cu(II) complex displayed the d−d transition band in the region 13,606 cm −1 which is due to 2Eg→2T2g transition.…”

Section: Magnetic Susceptibility and Electronic Spectral Studiesmentioning

confidence: 64%

“…The most important step in the development of metal complexes was perhaps the preparation of a new ligand, which exhibits unique properties and novel reactivity. Thus, the electron donor and electron acceptor properties of the ligand, structural functional groups, and the position of the ligand in the coordination sphere together with the reactivity of coordination compounds may be a factor of different studies [15,16,17,18,19,20,21,22,23,24,25,26,27]. Schiff's bases are compounds containing an azomethine group (−CH− −N−) which have drawn attention for many years ago.…”

Section: Introductionmentioning

confidence: 99%

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Structure Studies of the Prepared Novel Hydrazone Schiff’s Base Complexes Using Spectroscopic, Thermal Analyses and Their Biological Activities

Zayed¹,

Belal²,

Ragha³

2018

J Transition Met Complexes

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The complexing behavior of benzoylhydrazone Schiff's base (A1), with the IUPAC name (2(1-hydrazonoethyl)phenol), towards the transition metal ions, namely, Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Hg(II), Ce(IV), and UO 2 (II), has been examined by elemental analyses, magnetic measurements of some of them, electronic spectra, FT-IR, 1 H-NMR, and 13 C-NMR. Thermal properties and decomposition kinetics of all complexes are investigated. The interpretation of kinetic parameters of thermal decomposition stages of some of them has been evaluated using CoatsRedfern equation. The antifungal activities of the free ligand and its metal complexes have been tested in vitro against two types of fungi: Aspergillus fumigatus, RCMB 02568; Candida albicans, RCMB 05036. Besides, two gram-positive (Bacillus subtilis, RCMB 010067; Streptococcus pneumoniae, RCMB 010010) and two gram-negative (Escherichia coli, RCMB 010052; Pseudomonas aeruginosa, RCMB 010043) bacteria were used as test organisms in order to assess the complexes' antimicrobial potential. It is clear from this survey that the A1 complexes are of high biological activities as antifungal, in which Cu-A1 and Co-A1 are the most efficient complexes in a level more or less approaches that of the amphotericin standard. It also indicates that the Cu-A1 and Mn-A1 have the largest biological effects on gram-positive bacteria of both kinds, and that Cu-A1 complex has a more effect (32.4 ± 0.30) or of the same order of magnitude (23.8 ± 0.20) as that of the ampicillin standard (23.8 ± 0.2).

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Section: Magnetic Susceptibility and Electronic Spectral Studiesmentioning

confidence: 56%

Section: Magnetic Susceptibility and Electronic Spectral Studiesmentioning

confidence: 56%

Section: Magnetic Susceptibility and Electronic Spectral Studiesmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Structure Studies of the Prepared Novel Hydrazone Schiff’s Base Complexes Using Spectroscopic, Thermal Analyses and Their Biological Activities

Zayed¹,

Belal²,

Ragha³

2018

J Transition Met Complexes

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“…4 Large numbers of Schiff bases have shown to exhibit a wide range of biological activities, including antitumor 5 anti-bacterial 6,7 fungicidal 8 and anticarcinogenic. 9 properties. On the other hand, coordination compounds with heterocyclic Schiff base ligand has attracted much attention of the chemist in current years to find applications as potential drugs, 10,11 due to the presence of multifunctional groups.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antimicrobial Activity of some Metal Complexes Derived from Thiazole Schiff Bases with In-vitro Cytotoxicity and DNA Cleavage Studies

Karabasannavar¹,

Allolli²,

Shaikh³

et al. 2017

IJPER

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Five metal complexes with Schiff-base ligand, 3-((4-phenylthiazol-2-ylimino) methyl)-2-hydroxybenzoic acid were synthesized with metal ions such as Cu(II), Co(II), Ni(II), Cd(II) and Zn(II). The reaction likely proceeds via condensation of 2-amino-4-phenyl thiazole with 3-aldehydosalicylic acid and characterized by elemental analysis and various spectral studies like FT-IR, 1 H NMR, ESI mass, and TGA/TDA and molar conductance studies. The spectral results revealed bidentate O-O donor and forms the complexes having square planar geometry. The antibacterial and antifungal activity of the ligand and its metal complexes was found based on the determination of minimum inhibitory concentrations. The brine shrimp biological assay was also carry out to study the In vitro cytotoxicity properties for the ligand and its metal complexes against Artemia salina. Moreover, DNA cleavage experiments revealed that the Cu (II), Co (II) and Zn (II) complexes exhibited remarkable DNA cleavage activities via the generation of hydroxyl radical.

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Synthesis of novel macrocyclic Schiff's‐base and its complexes having N₂O₂ group of donor atoms. Characterization and anticancer screening are studied

Zayed

Fahim

et al. 2017

Applied Organom Chemis

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Novel Schiff base [N′,N′″-(((ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(methanylylidene))di(benzohydrazide)] was formed by the condensation reaction of benzohydrazide with 2,2′-(ethane-1,2-diylbis(oxy))dibenzaldehyde. Its reaction with various metal ions was studied and the structures of the new products were characterized using common analytical and spectroscopic methods. All the metal complexes have pronounced anticancer activities. The antimicrobial activities against Gram-negative and Gram-positive bacteria were investigated.

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Synthesis of novel Schiff’s bases of highly potential biological activities and their structure investigation

Cited by 62 publications

References 32 publications

Structure Studies of the Prepared Novel Hydrazone Schiff’s Base Complexes Using Spectroscopic, Thermal Analyses and Their Biological Activities

Structure Studies of the Prepared Novel Hydrazone Schiff’s Base Complexes Using Spectroscopic, Thermal Analyses and Their Biological Activities

Synthesis, Characterization and Antimicrobial Activity of some Metal Complexes Derived from Thiazole Schiff Bases with In-vitro Cytotoxicity and DNA Cleavage Studies

Synthesis of novel macrocyclic Schiff's‐base and its complexes having N₂O₂ group of donor atoms. Characterization and anticancer screening are studied

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Synthesis of novel Schiff’s bases of highly potential biological activities and their structure investigation

Cited by 62 publications

References 32 publications

Structure Studies of the Prepared Novel Hydrazone Schiff’s Base Complexes Using Spectroscopic, Thermal Analyses and Their Biological Activities

Structure Studies of the Prepared Novel Hydrazone Schiff’s Base Complexes Using Spectroscopic, Thermal Analyses and Their Biological Activities

Synthesis, Characterization and Antimicrobial Activity of some Metal Complexes Derived from Thiazole Schiff Bases with In-vitro Cytotoxicity and DNA Cleavage Studies

Synthesis of novel macrocyclic Schiff's‐base and its complexes having N2O2 group of donor atoms. Characterization and anticancer screening are studied

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Synthesis of novel macrocyclic Schiff's‐base and its complexes having N₂O₂ group of donor atoms. Characterization and anticancer screening are studied