Synthesis of novel water soluble onium salts and thieno[3,4-c]thiolactones – precursors of conductive materials derived from substituted 2-aminothiophenes

Abstract

Dedicated to Professor Rosa Lederkremer on her 70th anniversary AbstractThe synthetic utility in the area of synthesis of "smart" conductive materials of the easily accessible 2-aminothiophenes is described. Simple protection of amino group and subsequent radical bromination leads to brominated intermediates. The novel 4-bromomethylthiophene derivatives easily enter into reaction with tertiary amines and thiourea to give ammonium and thiouronium salts -novel water-soluble thiophenes. Thiouronium salts are predisposed to deliver substituted thieno[3,4-c]thiolactone derivatives, which are attractive from the point of view of their further utilization in the synthesis of thieno [3,4-c]thiophenes. Each of the mentioned compounds showed bioactivity as well as propensity to be polymerized to conductive oligomers and polymers.

Untitled

“…The above medium was inoculated at 1% level with 18 h old cultures of the above mentioned test organisms and was transferred into sterile petri dishes [13][14][15][16][17][18] . The medium in the plates was allowed to set at room temperature for about 10 min and they were set to solidify in a refrigerator for 30 min.…”