Synthesis of PHB-based carrier for drug delivery systems with pH-controlled release

Michalak, M.; Marek, A.; Zawadiak, Jan; Kawalec, Michał; Kurcok, Piotr

doi:10.1016/j.eurpolymj.2013.09.021

Cited by 55 publications

(29 citation statements)

References 43 publications

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“…Chemical systems based on stimuli‐responsive materials releasing loaded substances upon receiving external signals have been extensively studied in the last years due to many possible applications 1–4. The releasing processes activated by various physical and chemical signals 5, such as light 6, magnetic field 7, temperature change 8, pH variation 9, 10, presence of small biomolecules (e.g., glucose) 11 or proteins 12 and presence of bacterial cells 13 have been reported. Most of the developed systems were designed for biomedical applications, particularly for signal‐triggered drug release 14–17.…”

Section: Introductionmentioning

confidence: 99%

Electrochemically Stimulated DNA Release from a Polymer‐Brush Modified Electrode

et al. 2015

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Single‐stranded DNA molecules were loaded on the mixed poly(2‐vinylpyridine) (P2VP)/polyacrylic acid (PAA) brush covalently attached to an indium tin oxide (ITO) electrode. The DNA deposition was performed at pH 3.0 when the polymer brush is positively charged due to protonation of pyridine groups in P2VP, thus resulting in electrostatic binding of the negatively charged DNA. By applying electrolysis at −1.0 V (vs. Ag/AgCl reference) oxygen reduction resulted in the consumption of hydrogen ions and local pH increase in the vicinity of the electrode surface. The process resulted in the local pH ca. 7.5 which yielded the negative state of the mixed polymer‐brush due to dissociation of carboxylic groups of PAA. This resulted in the electrostatic repulsion and release of the loaded DNA. The developed approach allows cyclic load‐release of the DNA with the significantly increased amount of the released DNA comparing with previously reported systems. Further options for the improvements of the system are discussed.

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Section: Introductionmentioning

confidence: 99%

Electrochemically Stimulated DNA Release from a Polymer‐Brush Modified Electrode

et al. 2015

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“…Other PHAs oligomers, such as PHB macrodiols with a hydroxyl group and a double bond at different chain ends [65], PHB-amine conjugate containing hydrolysable imine bond [66], chlorination of PHAs (PHB or PHO) and their corresponding quaternary ammonium salts, sodium sulfate salts, and phenyl derivatives [67], have also been produced by various chemical methods. These PHAs oligomers could be used for building the block (diblock, triblock, or star block), graft, or even brush type graft copolymers of PHAs via different mechanism, mainly coupling reaction and macroinitiating reaction, to explore the suitable chemical and physical properties, processability and biocompatibility.…”

Section: Phas Copolymer Via An Oligomer-first Methodsmentioning

confidence: 99%

Synthetic routes to degradable copolymers deriving from the biosynthesized polyhydroxyalkanoates: A mini review

Ke¹,

Zhang²,

Ramakrishna³

et al. 2016

Express Polym. Lett.

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Abstract.Polyhydroxyalkanoates are a family of natural polyesters being produced as intracellular carbon and energy reserves by a wide variety of microorganisms. They have developed rapidly in both research and development efforts globally in the last 15 years. Till now, over 100 different types of PHAs have been successfully biosynthesized using both genetic engineering and fermentation techniques. Their unique biodegradable, biocompatible and thermoplastic characteristics make PHAs promising candidates for the commodity and biomedical applications. This review focused on the chemical synthesis of the derivatives of the biosynthesized PHAs.

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“…Such unsaturated end groups of OHB may be also ozonolyzed to the aldehyde function and used as PHA-based carriers for drug delivery systems with pH-controlled release [11]. The example of such reaction can be synthesis of oligo(3-hydroxybutyrate) glyoxylate shown in Scheme C.…”

Section: Pha Oligomers Contained Unsaturated End Groupsmentioning

confidence: 99%

Bioactive oligomers from natural polyhydroxyalkanoates and their synthetic analogues

2017

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Contemporary reports on the bioactive oligomers derived from natural aliphatic co-polyesters (PHA) and their synthetic analogues, formed through anionic ring-opening polymerization (ROP) of β-substituted β-lactones are presented. Synthetic routes for such oligomers, developed mostly by Polish authors, are discussed. The described approaches enable design of novel biodegradable and bioactive oligomers for diverse applications in medicine, cosmetic industry and agrochemistry. Otrzymywanie bioaktywnych oligomerów z naturalnych biopoliestrów i ich syntetycznych analogówStreszczenie: Przedstawiono przegląd aktualnych wyników badań dotyczących bioaktywnych oligomerów otrzymywanych z naturalnych alifatycznych ko-poliestrów (PHA) oraz ich syntetycznych analogów, uzyskanych na drodze anionowej polimeryzacji z otwarciem pierścienia (ROP) β-podstawionych β-laktonów. Omówiono ścieżki syntezy tych oligomerów opracowane głównie przez polskich badaczy. Zaprezentowane metody umożliwiają projektowanie nowych biodegradowalnych, a zarazem bioaktywnych oligomerów mogących znaleźć różnorodne zastosowania w medycynie, przemyśle kosmetycznym i agrochemii.Słowa kluczowe: poliester alifatyczny, anionowa polimeryzacja, oligomer bioaktywny, β-podstawiony β-lakton.

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Synthesis of PHB-based carrier for drug delivery systems with pH-controlled release

Cited by 55 publications

References 43 publications

Electrochemically Stimulated DNA Release from a Polymer‐Brush Modified Electrode

Electrochemically Stimulated DNA Release from a Polymer‐Brush Modified Electrode

Synthetic routes to degradable copolymers deriving from the biosynthesized polyhydroxyalkanoates: A mini review

Bioactive oligomers from natural polyhydroxyalkanoates and their synthetic analogues

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