Synthesis of Phenylurea Derivatives &amp; Their Evaluation as Antihyperglycaemic Agents

Four novel antimicrobial maleimido phenyl thiourea derivatives were synthesized from N- [4-(chlorocarbonyl) phenyl] maleimide with phenyl thiourea and its derivatives (p-methyl, o-chloro, and p-carboxy). Their structures were characterized by FTIR, 1 H NMR, mass spectra, and elemental analyses. Their antimicrobial activities against three types of bacteria (Bacillus subtilis, Streptococcus pneumoniae, and Escherichia coli) and against three crop-threatening pathogenic fungi (Aspergillus fumigatus, Geotricum candidum, and Syncephalastrum racemosum) were investigated. The results revealed that these derivatives are effective in inhibiting the growth of the tested bacteria and fungi as indicated from the inhibition zone diameter and minimum inhibitory concentration. The antibacterial activities of these derivatives were more effective against Gram-positive bacteria than Gram-negative bacteria. These derivatives were investigated as thermal stabilizers for rigid poly(vinyl chloride) at 180°C in air by measuring the rate of dehydrochlorination and the extent of discoloration. The results reveal the greater stabilizing efficiency of the investigated derivatives as shown by their longer thermal stability periods (Ts) and lower dehydrochlorination rates in relation to dibasic lead carbonate, cadmium-barium-zinc stearate, and n-octyltin mercaptide industrial stabilizers. The stabilizing efficiency increases with the introduction of electron-donating substituent groups in the aromatic ring of the stabilizer molecules. Moreover, the investigated stabilizers impart better color stability for the degraded samples as compared with the reference stabilizers. C 2015 Wiley Periodicals, Inc. Adv Polym Technol 2016, , 21537; View this article online at wileyonlinelibrary.com.

show abstract

Thermally Stable Antimicrobial PVC/Maleimido Phenyl Thiourea Composites

Mohamed

El‐Ghany

Fahmy

et al. 2015

Adv Polym Technol

View full text Add to dashboard Cite

show abstract

Rhodium(III)‐Catalyzed C−H Activation of O‐Acetyl Ketoximes/N‐Methoxybenzamides toward the Synthesis of Isoquinoline/Isoquinolone‐Fused Bicycles

2017

View full text Add to dashboard Cite

show abstract

Palladium‐Catalyzed Cross‐Coupling of Aryl Iodides with Heterobicyclic Olefins: Access to Hydroarylated and Heteroannulated Motifs

et al. 2017

View full text Add to dashboard Cite

Transition metal catalyzed synthetic transformations of bicyclic olefins have acquired considerable attention towards the construction of biologically relevant carbocycles and heterocycles. In this regard, urea derived bicyclic olefins grabbed our attention due to its tremendous biological significance and synthetic potential. Herein, we report a palladium catalyzed reductive Heck reaction of urea‐derived bicyclic olefins toward the synthesis of hydroarylated and heteroannulated motifs using aryl iodides. The reaction of aryl iodides in the presence of a hydrogen donor such as formic acid furnished the hydroarylated products in moderate to excellent yields. Heteroannulated products such as dihydrobenzofuran derivatives were obtained in moderate to good yields with 2‐iodophenols in the absence of a hydrogen donor. We were also successful in extending this strategy to 2‐iodobenzylbromide and 2‐iodobenzonitrile towards the synthesis of ring fused indane and indanone derivatives. To our dismay, the reactions with 2‐iodoaniline to provide the expected indoline derivatives remained futile. The presence of biologically significant urea moieties coupled with naturally as well as pharmaceutically prevalent carbo/heterocyclic derivatives in the products authenticate the relevance of the current synthetic strategy.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Synthesis of Phenylurea Derivatives & Their Evaluation as Antihyperglycaemic Agents

Cited by 6 publications

References 0 publications

Thermally Stable Antimicrobial PVC/Maleimido Phenyl Thiourea Composites

Thermally Stable Antimicrobial PVC/Maleimido Phenyl Thiourea Composites

Rhodium(III)‐Catalyzed C−H Activation of O‐Acetyl Ketoximes/N‐Methoxybenzamides toward the Synthesis of Isoquinoline/Isoquinolone‐Fused Bicycles

Palladium‐Catalyzed Cross‐Coupling of Aryl Iodides with Heterobicyclic Olefins: Access to Hydroarylated and Heteroannulated Motifs

Contact Info

Product

Resources

About