Synthesis of Physiological Active Terpenes. Part VI. Synthesis and Physiological Activity of Monoterpene Carboxypyrrolidinamides and Piperidinamides.

Antimicrobial and Tyrosinase Inhibitory Activities of 6-[(8Z)-8-Pentadecenyl]salicylic Acid Derivatives.

“…5, which showed that inhibition did not take place at the level of the interme-diate formed in the tyrosinase reaction but was a competitive process; that is, these compounds competed with the substrate, L-DOPA, for the active site of tyrosinase. From this observation, it was inferred that the type of compounds that have an optimal inhibitory effect on tyrosinase activity would be those with an oorientation in which the -COOH group and the -OH group can easily form an intramolecular hydrogen bond on the aromatic ring; in addition, it would be necessary [2] 12.5 12.5 12.5 6.25 100 50 800 800 800 800 800 800 800 400 [3] 50 50 25 50 50 100 800 800 800 800 800 800 800 800 [4] 400 400 400 400 400 3200 800 800 800 800 400 400 400 200 [8] 800 800 800 800 800 800 800 800 800 800 800 800 800 800 [5] 400 400 400 800 800 800 800 800 800 800 800 800 800 400 [6] 400 800 400 400 800 800 800 800 800 800 400 400 400 200 [7] 800 800 800 800 800 800 800 800 800 800 800 800 800 800 K. Kasemura, M. Noumura, T. Tada et al to introduce the -OH group into the monoolefin present in the C 15 side chain at the C 8 position, which would probably lead to a high percentage of inhibition. These noble derivatives, which showed strong inhibition of tyrosinase, were examined for their inhibition of melanogenesis and toxicity in B-16 melanoma cells.…”