Synthesis of poly(acrylamide-co-methyl methacrylate) chemically cross-linked hydrogels and their application in controlled release of model drugs

Begam, Tamanna; Nagpal, A. K.; Singhal, Reena

doi:10.1163/156855506778538083

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…They were promptly weighed and reverted to their containers. The volume fraction of polymer (ɸ 2 ), extension ratio (ER), weight loss of xerogels during swelling, and water content (EWC) were calculated as [13]:…”

Section: Procedures Of Swellingmentioning

confidence: 99%

Synthesis and Characterization of (Methyl Methacrylate/Phenyl Acrylamide) Hydrogel for Biomedical Applications

Abed

Mohammed

2021

Egypt. J. Chem.

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The basic explorations of structure property correlations and the variety of commercial and biological applications all attest to the fact that amphiphilic is highly useful. In this work, the monomer phenyl acrylamide was synthesized by reacting acrylamide with chloro benzene in the presence of pyridine. Two series of Poly (phenyl acrylamide-co-methyl methacrylate) (poly(PAAm-co-MMA)) hydrogels have been prepared, series 1 composed of PAAm/MMA copolymers covering a range of composition (60-90% PAAm) while series 2 composed of 90PAAm/10MMA copolymer containing 1, 2, 3, and 4 wt% of N,N'-methylenebisacrylamide (MBAA) as crosslinker. Fourier transform infrared spectroscopy (FT-IR) was used to characterize the resulting monomer and polymers. The effects of the monomer ratio and added crosslinker on the swelling behavior and mechanical properties of poly (PAAm-co-MMA) hydrogels were investigated. Swelling parameters such as volume fraction of polymer (φ2), weight loss during swelling were determined. Depending on shear and Young's modulus (G and E), network parameters such as polymer-solvent interaction (χ), cross-link density (ve), and molecular mass between cross-links (Mc) were calculated. The ability of series 1 hydrogels for use in controlled release of drugs such as ciprofloxacin was also studied. Results revealed that during the first 10 hours, most of the drug load is released.

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Section: Procedures Of Swellingmentioning

confidence: 99%

Synthesis and Characterization of (Methyl Methacrylate/Phenyl Acrylamide) Hydrogel for Biomedical Applications

Abed

Mohammed

2021

Egypt. J. Chem.

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“…The hydrogels of polymers based on acrylamide (PAAm), have been studied for a considerable number of applications. Some of these applications include drug delivery (22)(23)(24)(25), systems of concentration against gradient (26), water remediation (27,28), etc. However, these hydrogels are usually modified to provide different properties, such as a specific response to external stimuli, better mechanical properties or better biocompatibility, between others (29).…”

Section: Introductionmentioning

confidence: 99%

“…Bagam at al. (23) have synthesized the Poly(acrylamide-co-methyl methacrylate) (poly(AAm-co-MMA)) hydrogels with chemical cross-links using cross-linker (N,N-methylene bis acrylamide) in different stoichiometric ratios and studied the ability of this co-polymeric hydrogel for use in controlled release of model drugs such as benzoic acid , salicylic acid and p-nitroaniline.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of poly(acrylamide-co-methyl methacrylate) chemicaly cross-linked hydrogels for efficient adsorption of red erionyl dye

et al. 2022

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Polyacrylamide (Poly (AAm)) and poly(acrylamide-co-methyl methacrylate) (poly (AAm-co-MMA)) hydrogels were synthesized by solution free radical polymerization initiated by Potassium persulfate initiator (KPS) at different feed mol monomer ratios and N,N-methylene bisacrylamide (BIS) as a crosslinking agent. The obtained hydrogels were characterized by FTIR, scanning electron microscopy (SEM) and swelling behaviour. The swelling properties of Poly (AAm) and poly (AAm-co-MMA) hydrogels were studied in distilled water at different pH. The effect of temperature on swelling behaviour of these hydrogels has been analysed by variation from 25 to 50?C. Poly(AAm-co-MMA) hydrogels were considered for the removal of Red Erionyl textile dyes from aqueous solutions. Two kinetics models were applied; the first and the second order kinetics as well as the Freundlich and Langmuir isotherms were tested. The result confirms that the adsorption process of Red Erionyl dye follows second-order kinetics and their equilibrium data were fitted well to the linear Langmuir model.

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“…Many works have been reported in the literature on the enhancement of certain key properties that adapt with the conditions of the specific environment in which such polymers operate. Recently, pH-sensitive hydrogels, such as poly(acrylic acid) (PAA) [9], poly(methacrylic acid) [10], poly(vinylpyrolidone/acrylic acid [11], poly(vinylalcohol) [12], poly(acrylamide- co -methylmethacrylate) [13], poly(acrylamide-2-acrylamido-2-methyl-1-propanesulfonic acid) [14], and other methacrylic-type polymeric prodrugs, have become more attractive in the drug delivery domain. The substances produced from these polymers, when crosslinked, swell in water or aqueous solutions below the lower critical solution temperature (LCST) and shrink above the LCST.…”

Section: Introductionmentioning

confidence: 99%

Poly(ethylene-co-vinylalcohol)/Poly(δ-valerolactone)/Aspirin Composite: Model for a New Drug-Carrier System

et al. 2019

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The release dynamics of aspirin(ASP), used as a drug model, from the poly(ethylene-co-vinyl alcohol)/poly(δ-valerolactone) (PE-co-VAL/Pδ-VL) hydrogel blend was controlled by varying the blend’s degree of swelling through a gradual loading of Pδ-VL (hydrophobic polymer) in this copolymer matrix. To achieve this goal, a series of PE-co-VAL/Pδ-VL blends with different ratios was prepared through the solvent casting method, and the miscibility of this polymer blend was evaluated by using Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, and scanning electronic microscopy methods. The tests of cell adhesion and growth on the PE-co-VAL/Pδ-VL specimens were performed using the 3-(4,5-demethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and the results obtained were the best performance in terms of cell viability, cell adhesion, and growth of the PE-co-VAL/Pδ-VL50 material. The dynamic mechanical properties of the prepared material were also examined by dynamic mechanical analysis; the results obtained showed a material having intermediary mechanical properties between those of the two components. On the basis of these characterizations, the blend showing the best performance, such as the PE-co-VAL/Pδ-VL50 system, was chosen as a carrier to study the in vitro control of the release dynamics of ASP from the ASP/PE-co-VAL/Pδ-VL drug-carrier system when administered orally, in which the influences of the ASP content and the degree of swelling of the PE-co-VAL/Pδ-VL blend were investigated. Based on the data obtained and the gastrointestinal transit time reported by Beltzer et al., it was possible to estimate the distribution of the in vitro cumulative ASP released in different digestive system organs regardless of the actions of any enzymes and microorganisms and select the best-performing drug-carrier system.

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Synthesis of poly(acrylamide-co-methyl methacrylate) chemically cross-linked hydrogels and their application in controlled release of model drugs

Cited by 7 publications

References 15 publications

Synthesis and Characterization of (Methyl Methacrylate/Phenyl Acrylamide) Hydrogel for Biomedical Applications

Synthesis and Characterization of (Methyl Methacrylate/Phenyl Acrylamide) Hydrogel for Biomedical Applications

Synthesis of poly(acrylamide-co-methyl methacrylate) chemicaly cross-linked hydrogels for efficient adsorption of red erionyl dye

Poly(ethylene-co-vinylalcohol)/Poly(δ-valerolactone)/Aspirin Composite: Model for a New Drug-Carrier System

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