Synthesis of Poly(lactide)s with Modified Thermal and Mechanical Properties

Becker, Jeff; Pounder, Ryan J.; Dove, Andrew P.

doi:10.1002/marc.201000088

Cited by 138 publications

(92 citation statements)

References 98 publications

(129 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are often biocompatible and biodegradable, and offer thermal, physical, and mechanical properties which are complementary or comparable to those of some oil-based polymers [40][41][42][43][44][45]. Monomers such as ε-caprolactone (CL) or Glycolide (GL) have long been employed by organometallic and polymer chemists, but more recently green monomers like lactide (LA) and trimethylene carbonate (TMC) have emerged as particularly attractive raw materials since they are derived from annually renewable resources (Fig.…”

Section: Polymerization Of Cyclic Esters and Carbonates: General Aspectsmentioning

confidence: 99%

Alkaline-Earth Metal Complexes in Homogeneous Polymerization Catalysis

Carpentier

Sarazin

2013

Alkaline-Earth Metal Compounds

View full text Add to dashboard Cite

This chapter describes the use of complexes of the alkaline-earth metals (magnesium, calcium, strontium, and barium) in homogeneous polymerization catalysis. The latest developments in the polymerization of monomers containing C=C unsaturations (ethylene, styrene, dienes, acrylates) and in the ring-opening polymerization (ROP) of cyclic esters [lactides (LA), ε-caprolactone, trimethylene carbonate] are covered. The mechanisms of chain growth polymerization of olefins and immortal ROP of cyclic esters, which is of particular relevance to these metals, are presented. In view of the current interest devoted to the organometallic chemistry of the larger alkaline-earth metals, the implementation of well-defined catalyst systems based on calcium, strontium, and barium for the polymerizations of styrene and lactide is highlighted

show abstract

Section: Polymerization Of Cyclic Esters and Carbonates: General Aspectsmentioning

confidence: 99%

Alkaline-Earth Metal Complexes in Homogeneous Polymerization Catalysis

Carpentier

Sarazin

2013

Alkaline-Earth Metal Compounds

View full text Add to dashboard Cite

show abstract

“…An overview of the synthetic methods applied to modify PLA properties has been given by Dove and co-workers. [ 9 ] One important strategy to generate unusual rheological and mechanical properties for PLA is the design of branched architectures. [10][11][12][13] In contrast to their linear counterparts branched PLA polymers exhibit lower glass transitions and melting temperatures.…”

Section: Introductionmentioning

confidence: 99%

Organobase‐Catalyzed Synthesis of Multiarm Star Polylactide With Hyperbranched Poly(ethylene glycol) as the Core

Schömer

Frey

2011

Macro Chemistry & Physics

View full text Add to dashboard Cite

Multiarm star copolymers consisting of the polyether-polyol hyperbranched poly(ethylene glycol) ( hb PEG) as core and poly( L -lactide) (PLLA) arms are synthesized via the organobasecatalyzed ring-opening polymerization of lactide using hb PEG as a multifunctional macroinitiator. Star copolymers with high molecular weights up to 792 000 g mol − 1 are prepared. Detailed 2D NMR analysis provides evidence for the attachment of the PLLA arms to the core and reveals that the adjustment of the monomer/initiator ratio enables control of the arm length. Size exclusion chromatography measurements show narrow molecular weight distributions. Thermal analysis reveals a lower glass transition temperature, melting point, and degree of crystallization for the star-shaped polylactides compared to linear polylactide.

show abstract

“…The temperature was set at 65 °C, which is above the T g of polylactide. 25 After 30 h, well-defined PLLA- b -PAA cylindrical micelles 3 were obtained. To achieve shorter cylindrical nanoparticles 2 , the ratio between the THF and H 2 O in the assembly mixture was adjusted to 5/95, while all the other conditions remained the same.…”

mentioning

confidence: 99%

Shape Effect of Glyco-Nanoparticles on Macrophage Cellular Uptake and Immune Response

et al. 2016

Self Cite

View full text Add to dashboard Cite

The shells of various poly(dl-lactide)-b-poly(acrylic acid) (PDLLA-b-PAA) spherical micelles and poly(l-lactide)-b-poly(acrylic acid) (PLLA-b-PAA) cylindrical micelles were functionalized with mannose to yield glyco-nanoparticles (GNPs) with different shapes and dimensions. All of these GNPs were shown to have good biocompatibility (up to 1 mg/mL). Cellular uptake experiments using RAW 264.7 have shown that the spherical GNPs were internalized to a much greater extent than the cylindrical GNPs and such a phenomenon was attributed to their different endocytosis pathways. It was demonstrated that spherical GNPs were internalized based on clathrin- and caveolin-mediated endocytosis while cylindrical GNPs mainly depended on clathrin-mediated endocytosis. We also found that longer cylindrical GNPs (Ln × Wn = 215 × 47 nm) can induce an inflammatory response (specifically interleukin 6) more efficiently than shorter cylindrical GNPs (Ln × Wn = 99 × 50 nm) and spherical GNPs (Dn = 46 nm).

show abstract

Synthesis of Poly(lactide)s with Modified Thermal and Mechanical Properties

Cited by 138 publications

References 98 publications

Alkaline-Earth Metal Complexes in Homogeneous Polymerization Catalysis

Alkaline-Earth Metal Complexes in Homogeneous Polymerization Catalysis

Organobase‐Catalyzed Synthesis of Multiarm Star Polylactide With Hyperbranched Poly(ethylene glycol) as the Core

Shape Effect of Glyco-Nanoparticles on Macrophage Cellular Uptake and Immune Response

Contact Info

Product

Resources

About