Synthesis of polyglycerol-citric acid nanoparticles as biocompatible vectors for biomedical applications

Bodaghi, Ali; Adeli, Mohsen; Dadkhahtehrani, Abbas; Tu, Zhaoxu

doi:10.1016/j.molliq.2017.06.087

Cited by 11 publications

(8 citation statements)

References 20 publications

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“…Because of huge surface functionalities existed into the surface of PG-CA-NPs, it shows the higher cellular uptake and biocompatibility. Owing to the simple and straightforward synthesis approach, it can be used for various future biomedical applications [43]. Yet a similar line of work has been reported by Mani and co-author.…”

Section: Ca-based Branched Polymer Nanoconjugatesmentioning

confidence: 66%

Pharmaceutical applications of citric acid

et al. 2021

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Background Citric acid (CA) is a universal plant and animal-metabolism intermediate. It is a commodity chemical processed and widely used around the world as an excellent pharmaceutical excipient. Notably, CA is offering assorted significant properties viz. biodegradability, biocompatibility, hydrophilicity, safety, etc. Therefore, CA is broadly employed in many sectors including foodstuffs, beverages, pharmaceuticals, nutraceuticals, and cosmetics as a flavoring agent, sequestering agent, buffering agent, etc. From the beginning, CA is a regular ingredient for cosmetic pH-adjustment and as a metallic ion chelator in antioxidant systems. In addition, it is used to improve the taste of pharmaceuticals such as syrups, solutions, elixirs, etc. Furthermore, free CA is also employed as an acidulant in mild astringent preparations. Main text In essence, it is estimated that the functionality present in CA provides excellent assets in pharmaceutical applications such as cross-linking, release-modifying capacity, interaction with molecules, capping and coating agent, branched polymer nanoconjugates, gas generating agent, etc. Mainly, the center of attention of the review is to deliver an impression of the CA-based pharmaceutical applications. Conclusion In conclusion, CA is reconnoitered for multiple novels pharmaceutical and biomedical/applications including as a green crosslinker, release modifier, monomer/branched polymer, capping and coating agent, novel disintegrant, absorption enhancer, etc. In the future, CA can be utilized as an excellent substitute for pharmaceutical and biomedical applications. Graphical abstract

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Section: Ca-based Branched Polymer Nanoconjugatesmentioning

confidence: 66%

Pharmaceutical applications of citric acid

et al. 2021

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“…The results approved that the incorporation of CA segments within the polyglycerol structure improves the biocompatibility and biodegradability of PGCN. Based on the obtained results from the (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) and cell uptake against MCF7 cells the authors proposed that the PGCN is a promising object for future biomedical usages in which drug delivery could be one of them 60 …”

Section: Ca‐based Ddssmentioning

confidence: 99%

“…Based on the obtained results from the (3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and cell uptake against MCF7 cells the authors proposed that the PGCN is a promising object for future biomedical usages in which drug delivery could be one of them. 60 The efficiency of the prepared hyperbranched PCA for delivery of the paclitaxel (PTX) and its cytotoxicity against the A549 and SKOV3 cell lines were evaluated by Sobhani et al In this study, at first, multiwalled carbon nanotubes (MWNTs) were functionalized with hyperbranched PCA. Afterward, the PTX was conjugated by the formation of a hydrolyzable ester bond (MWNT-g-PCA-PTX).…”

Section: Ca-based Hyperbranched Polymermentioning

confidence: 99%

Application or function of citric acid in drug delivery platforms

Pooresmaeil

Javanbakht

Namazi

et al. 2021

Medicinal Research Reviews

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Nontoxic materials with natural origin are promising materials in the designing and preparation of the new drug delivery systems (DDSs). Today's, citric acid (CA) has attracted a great deal of attention because of its special features; green nature, biocompatibility, low price, biodegradability, and commercially available property. So, CA has been employed in the preparation of the various platforms to induce a suitable property on their structure. Recently, several research groups investigated the CA‐based platforms in different forms like tablets, dendrimers, hyperbranched polymers, (co)polymer, hydrogels, and nanoparticles as efficient DDSs. By considering an increasing amount of published articles in this field, for the first time, in this review, an overview of the published works regarding CA applications in the design of various DDSs is presented with a detailed and insightful discussion.

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“…35 In this way, modern drug delivery systems can be created. 36 The described methods of obtaining PGCit rely on the use of appropriate catalysts such as PTSA, ZnCl 2 , and gentamicin. 37 Unfortunately, authors carry out their syntheses for a very long time, even 48 h, often at high temperatures of 170 °C.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Various active substances, including cis -platinum (cancer drug), can be incorporated into the dendrimeric product molecule . In this way, modern drug delivery systems can be created . The described methods of obtaining PGCit rely on the use of appropriate catalysts such as PTSA, ZnCl 2 , and gentamicin .…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Polycondensation of Citric Acid with Glycerol Based on a Genetic Algorithm

Wrzecionek

Matyszczak

Bandzerewicz

et al. 2021

Org. Process Res. Dev.

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Poly(glycerol citrate) is a biodegradable aliphatic polyester made of citric acid and glycerol. Because of the high functionality of the reactants, citric acid4 and glycerol3, there are many possibilities for creating different polymer chain structures. In this work, the polycondensation of citric acid with glycerol and its kinetics were studied through the kinetic model, allowing for estimation of relevant kinetic constants values for the first time with the employment of a genetic algorithm. The proposed kinetic model is multidimensional and contains eight parameters. The values of kinetic constants of the reaction included in our kinetic model were estimated. Relevant Arrhenius plots justify the applied model because of values of the R 2 coefficient of nearly 1.0. Considerations on the competitiveness of various reactionary acts are presented.

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Synthesis of polyglycerol-citric acid nanoparticles as biocompatible vectors for biomedical applications

Cited by 11 publications

References 20 publications

Pharmaceutical applications of citric acid

Pharmaceutical applications of citric acid

Application or function of citric acid in drug delivery platforms

Kinetics of Polycondensation of Citric Acid with Glycerol Based on a Genetic Algorithm

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