Synthesis of Polymeric Hydrogel Loaded with Antibiotic Drug for Wound Healing Applications

Zafalon, Angelica T.; Santos, Verônica Jorge; Esposito, Fernanda; Lincopán, Nilton; Rangari, Vijaya K.; Lugão, Ademar B.; Parra, D.F.

doi:10.1007/978-3-319-72484-3_18

Cited by 8 publications

(7 citation statements)

References 32 publications

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“…Although hydrogels display these interesting features, they suffer from several limitations such as their requirement for a secondary dressing, they can cause skin maceration, they can cause dehydration if not covered, exhibit poor mechanical properties in swollen state, etc. Their poor mechanical properties are usually overcome by preparing them from a combination of biopolymers and synthetic polymers, leading to hydrogels with excellent mechanical features [ 60 ]. Several researchers have reported polymer-based hydrogels loaded with curcumin.…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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“…Moreover, hydrogels loaded with these drugs can be useful as dressings in wound care [111]. The PVP/PEO/Agar γ-irradiated hydrogels loaded with neomycin drug showed a neomycin release of about 40% in 48 h [148].…”

Section: Drug Releasementioning

confidence: 99%

Properties and Applications of Biomaterials Related to Gels

2023

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As an excellent biopolymer material, hydrogel has been widely used in drug delivery, tissue engineering, and disease treatment, among other applications. By combining different polymers through physical or chemical changes, the prepared hydrogels can show better performance and be used in various environments.At present, the exploration of hydrogel in biomedicine seems to be diversified. To adapt to the complex environment in organisms, higher requirements must put forward for hydrogel. Under the premise that hydrogel is biosafe, it must become tougher or more easily degradable according to the purpose of its application, be able to stay in the body for a longer time to exert its effect, or be easily removed. Moreover, certain hydrogels can respond to changes in pH, temperature, biological indicators, or microorganisms in the body. We are interested in the intelligent properties of hydrogels, and the condition in which these properties can be used to facilitate their applications is undoubtedly a question that researchers need to consider carefully. This reprint consists of 12 papers, of which 2 are editorials and 10 are research papers. We hope to share the experimental and research results in this field and inspire new ideas for the design and applications of hydrogels.

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“…63 PVP hydrogels loaded with antibiotic neomycin demonstrated a controlled release of antibiotics onto the site against S. aureus. 64 However, PVP-chitosan hydrogels loaded with silver nanoparticles brought about a rapid reduction in the wound size and exhibited antibacterial activity against P. aeruginosa and S. aureus. 65 Polyethylene glycol (PEG) is a synthetic hydrophilic polymer used in medical products that are non-toxic and inert.…”

Section: Anti-inflammatory and Antibiotics Based Hydrogelsmentioning

confidence: 99%

“…In another study, PVP/carrageenan hydrogels composed of silver nanoparticles showed potential microbicidal activity against P. aeruginosa , S. aureus , E. coli , and Candida albicans to control wound infection and also healing of burns and skin injuries 63 . PVP hydrogels loaded with antibiotic neomycin demonstrated a controlled release of antibiotics onto the site against S. aureus 64 . However, PVP‐chitosan hydrogels loaded with silver nanoparticles brought about a rapid reduction in the wound size and exhibited antibacterial activity against P. aeruginosa and S. aureus 65 .…”

Section: Anti‐inflammatory and Antibiotics Based Hydrogelsmentioning

confidence: 99%

Applications ofhydrogel‐baseddelivery systems in wound care and treatment: Anup‐to‐datereview

Divyashri

Badhe

Sadanandan

et al. 2022

Polymers for Advanced Techs

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Natural wound healing is a highly complex and regulated process. Disruption and barriers to cellular and tissue repair processes contributes to impaired wound healing, including sustained infections. Superficial wound healing requires many factors to work in concrete at the wound site, and thus many treatment options and wound dressings have evolved to address the barriers to wound healing. Biomaterials are proven to encourage the wound healing process by stimulating repair and regeneration of injured tissues and preventing wound infections. A wide range of natural and synthetic hydrophilic and porous formulations such as foams, films, fibers, and hydrogels have been examined for these applications. Among these formulations, polymeric hydrogels have gained considerable interest in the medical applications. They effectively absorb wound exudates and provide a moist environment for aiding the wound healing process. However, chronic wounds that are sustained longer might need supplementary healing features as addendums such as antimicrobials, stem cells, growth factors, peptides, vitamins, and natural compounds. Therefore, when combined with hydrogels healing supporting addendums promote rapid and effective wound healing. Although there have been several advancements in biopolymer-based hydrogel systems, only limited reviews on various management strategies in wound healing are available in medical research and applications.Therefore, in this review, we have compiled and integrated various hydrogel-based approaches with the potential to improve chronic wound healing and advance important outcomes. In addition, in-situ injectable hydrogel preparation that have the advantage of packing patient wounds of different sizes and using 3D printing based tailor-made hydrogels, and bio-inks for wound closure applications are also highlighted.

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Synthesis of Polymeric Hydrogel Loaded with Antibiotic Drug for Wound Healing Applications

Cited by 8 publications

References 32 publications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Properties and Applications of Biomaterials Related to Gels

Applications ofhydrogel‐baseddelivery systems in wound care and treatment: Anup‐to‐datereview

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