Synthesis of polymeric nano/microgels: a review

Hamzah, Yusof; Hashim, Shahrin; Rahman, Wan Aizan Wan Abdul

doi:10.1007/s10965-017-1281-9

Cited by 66 publications

(43 citation statements)

References 106 publications

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“…These include high hydrophilicity, high loading capacity for drugs, high biocompatiblity, softness, and swelling. But the main advantage of nanogels is their fast response to environmental changes, which can help control their response at the target site (Arnfast, Madsen, Jorgensen, & Baldursdottir, 2014;Hamzah, Hashim, & Rahman, 2017;Soni, Desale, & Bronich, 2016). Despite these benefits, high cost requiring to remove the solvents and surfactants at the end of preparation, and toxicity resulting from remained surfactant or monomer traces are drawbacks (Zarekar, Lingayat, & Pande, 2017).…”

Section: Encapsulated 17-aag In Nanogelsmentioning

confidence: 99%

Spotlight on 17‐AAG as an Hsp90 inhibitor for molecular targeted cancer treatment

et al. 2019

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Hsp90 is a ubiquitous chaperone with important roles in the organization and maturation of client proteins that are involved in the progression and survival of cancer cells. Multiple oncogenic pathways can be affected by inhibition of Hsp90 function through degradation of its client proteins. That makes Hsp90 a therapeutic target for cancer treatment. 17‐allylamino‐17‐demethoxy‐geldanamycin (17‐AAG) is a potent Hsp90 inhibitor that binds to Hsp90 and inhibits its chaperoning function, which results in the degradation of Hsp90's client proteins. There have been several preclinical studies of 17‐AAG as a single agent or in combination with other anticancer agents for a wide range of human cancers. Data from various phases of clinical trials show that 17‐AAG can be given safely at biologically active dosages with mild toxicity. Even though 17‐AAG has suitable pharmacological potency, its low water solubility and high hepatotoxicity could significantly restrict its clinical use. Nanomaterials‐based drug delivery carriers may overcome these drawbacks. In this paper, we review preclinical and clinical research on 17‐AAG as a single agent and in combination with other anticancer agents. In addition, we highlight the potential of using nanocarriers and nanocombination therapy to improve therapeutic effects of 17‐AAG.

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Section: Encapsulated 17-aag In Nanogelsmentioning

confidence: 99%

Spotlight on 17‐AAG as an Hsp90 inhibitor for molecular targeted cancer treatment

et al. 2019

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“…The name 'microgel' was introduced more than six decades ago to describe soft colloidal particles, with characteristic sizes of up to several microns, made of a permanently crosslinked network of diluted polymers [1][2][3][4]. Nowadays, the growing importance of nanoscale systems has introduced a practical distinction between microgels-with sizes ranging from 0.1 to 100 µm-and nanogels-with sizes up to 100 nm-that is becoming widespread.…”

Section: Introductionmentioning

confidence: 99%

“…Their responses include large structural changes, typically swelling/collapse transitions, and a complex rheology [11,12]. Such a plethora of responsive possibilities became available in recent years thanks to the rapid development of synthesis techniques [3,4,13,14]. The most common among such techniques are the ones based on the polymerization of diluted monomers in presence of crosslinking agents, either in homogeneous solutions or in emulsion droplets.…”

Section: Introductionmentioning

confidence: 99%

The influence of an applied magnetic field on the self-assembly of magnetic nanogels

Novikau

Sánchez

Kantorovich

2020

Journal of Molecular Liquids

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Using Langevin dynamics simulations, we investigate the self-assembly of magnetic nanogels in the presence of applied magnetic fields of moderate strength. We find that even weak fields lead to drastic changes in the structure factors of both, the embedded magnetic nanoparticles and of whole nanogel particles. Nanogels assemble by uniting magnetic particle clusters forming inter-gel bridges. At zero field the average amount of such bridges for a pair of nanogels is close to one, whereas even for weak fields it fastly doubles. Rapid growth of cluster size at low values of the applied field is followed by a broad region of slow increase, caused by the mechanical constraints imposed the polymer matrix. The influence of the latter manifests itself in both, the slow growth of the magnetisation curve at intermediate fields and the slow decay of the total Zeeman energy.

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“…The concept of microgel is almost 70 years old [1]. The term refers to a colloidal soft particle made of a permanently crosslinked network of polymers, whose size can range from tens of nanometers to several micrometers [2,3]. Microgels can be made responsive to different stimuli, as temperature, pH or external fields [4,5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Suspensions of magnetic nanogels at zero field: Equilibrium structural properties

Novikau

Minina

Sánchez

et al. 2020

Journal of Magnetism and Magnetic Materials

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A B S T R A C TMagnetic nanogels represent a cutting edge of magnetic soft matter research due to their numerous potential applications. Here, using Langevin dynamics simulations, we analyse the influence of magnetic nanogel concentration and embedded magnetic particle interactions on the self-assembly of magnetic nanogels at zero field. For this, we calculated radial distribution functions and structure factors for nanogels and magnetic particles within them. We found that, in comparison to suspensions of free magnetic nanoparticles, where the self-assembly is already observed if the interparticle interaction strength exceeds the thermal fluctuations by approximately a factor of three, self-assembly of magnetic nanogels only takes place by increasing such ratio above six. This magnetic nanogel self-assembly is realised by means of favourable close contacts between magnetic nanoparticles from different nanogels. It turns out that for high values of interparticle interactions, corresponding to the formation of internal rings in isolated nanogels, in their suspensions larger magnetic particle clusters with lower elastic penalty can be formed by involving different nanogels. Finally, we show that when the self-assembly of these nanogels takes place, it has a drastic effect on the structural properties even if the volume fraction of magnetic nanoparticles is low.

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Synthesis of polymeric nano/microgels: a review

Cited by 66 publications

References 106 publications

Spotlight on 17‐AAG as an Hsp90 inhibitor for molecular targeted cancer treatment

Spotlight on 17‐AAG as an Hsp90 inhibitor for molecular targeted cancer treatment

The influence of an applied magnetic field on the self-assembly of magnetic nanogels

Suspensions of magnetic nanogels at zero field: Equilibrium structural properties

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