Synthesis of porous hydroxyapatite scaffolds from waste cockle shells by polyurethane sponge replication method

Abstract

Researchers have synthesized hydroxyapatite-based porous scaffolds by the polyurethane sponge replication methods. Hydroxyapatite was derived from waste cockle shells through the co-precipitation method. The synthesis of porous scaffolds through the sponge replication methods is carried out by absorbing hydroxyapatite slurry through the addition of PVA and then followed by heating at 900 o C to decompose the polyurethane and PVA. The best of slurry that can produce a porous scaffold in this study is the slurry that prepared through the ratio of hydroxyapatite:PVA = 80:20. The decomposition of the two polymers will leave macropores on the scaffold with an average size of 460 μm. Based on the thermogravimetric analysis, X-ray diffraction and FTIR spectrophotometer revealed that the PVA and polyurethane sponge were correctly decomposed, except for scaffolds with 40% PVA. Thus, the porous scaffolds synthesized in this study satisfies the requirements of porous scaffolds for the bone therapy process.

Innovating Hardness Model of Bioceramics Hydroxyapatite Based on Variety of Synthetic Conditions

“…Those researches are great importance to develop since hydroxyapatite has poor mechanical property. Hydroxyapatite is brittle [6,7]. That is why it is worry some when applied on bone since it may not be capable for holding the weight during the process of therapy.…”