Synthesis of Ptaeroxylin (Desoxykarenin): An Unusual Chromone from the Sneezewood Tree<i>Ptaeroxylon obliquum</i>

New, high‐yield derivatives of oxepino[3,2‐c]chromene were synthesized through a multicomponent reaction. This reaction involved 2‐hydroxyacetophenone, dimethyl carbonate, activated acetylenic compounds, and alkyl bromide. The reaction took place at room temperature in an aqueous environment, resulting in the formation of these innovative compounds. Oxathiepines were synthesized using multicomponent reactions of 2‐hydroxyacetophenone, dimethyl carbonate, isothiocyanate, and alkyl bromide in water at room temperature. This technology offers several benefits, including quick response times, high product yields, and easy product separation using straightforward techniques.

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Synthesis of Ptaeroxylin (Desoxykarenin): An Unusual Chromone from the Sneezewood TreePtaeroxylon obliquum

Abstract: The first synthesis of the oxepinochromone ptaeroxylin (also known as desoxykarenin) isolated from the sneezewood tree is described, in which the key steps are a Claisen rearrangement and a ring-closing metathesis to form the seven-membered oxygen heterocyclic ring.

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Formation of Ethers by Alkylation of Alcohols, Phenols, and Derivatives

Formation of Ethers by Alkylation of Alcohols, Phenols, and Derivatives

ChemInform Abstract: Synthesis of Ptaeroxylin (Desoxykarenin): An Unusual Chromone from the Sneezewood Tree Ptaeroxylon obliquum.

A highly effective method for the environmentally friendly production of novel chromene derivatives using electron deficient compounds

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