Synthesis of pure (ligandless) titanium nanoparticles by EB-PVD method

Kurapov, Yurii A.; Litvin, S. E.; Belyavina, N. N.; Oranskaya, Е. I.; Romanenko, Sergei M.; Stelmakh, Y. A.

doi:10.1007/s11051-020-05110-3

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Gold nanoparticles (AuNPs) already found wide applications in medicine-in optical visualization, target photosensitization, as sensitizers in radiotherapy of tumors, and as carriers for different drug molecules (antioxidants, immunomodulators, etc.) [1][2][3][4][5][6]. The ability of AuNPs to cause oxidative stress reported in several studies [7,8] allows their applications as sensitizers [9].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

Ivlieva

Petritskaya

Рогаткин

et al. 2023

IJMS

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The influence of gold nanoparticles after their prolonged oral administration to mice (during pregnancy and lactation) on spatial memory and anxiety levels in offspring was investigated. Offspring were tested in the Morris water maze and in the elevated Plus-maze. The average specific mass content of gold which crossed the blood–brain barrier was measured using neutron activation analysis and constituted 3.8 ng/g for females and 1.1 ng/g for offspring. Experimental offspring showed no differences in spatial orientation and memory compared to the control, while their anxiety levels increased. Gold nanoparticles influenced the emotional state of mice exposed to nanoparticles during prenatal and early postnatal development, but not their cognitive abilities.

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Section: Introductionmentioning

confidence: 99%

“…The ability of AuNPs to cause oxidative stress reported in several studies [7,8] allows their applications as sensitizers [9]. Because of the chemical inertness of gold [10], AuNPs are among the least toxic nanoparticles for mammals [3].…”

Section: Introductionmentioning

confidence: 99%

Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

Ivlieva

Petritskaya

Рогаткин

et al. 2023

IJMS

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Assessment of Gold Nanoparticles Uptake in Tissues of Female Mice and Their Offspring Using Neutron Activation Analysis

Ivlieva¹,

Zinicovscaia

Petritskaya³

et al. 2022

IFMBE Proceedings

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Effect of pure (ligand-free) nanoparticles of magnetite in sodium chloride matrix on hematological indicators, blood gases, electrolytes and serum iron

Lytvyn,

Vazhnichaya,

Manno

et al. 2024

Micro and Nano Syst Lett

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One of the physical methods for obtaining magnetite nanoparticles (NPs) is electron beam physical vapor deposition (EB PVD), which requires complex equipment, but allows obtaining a significant amount of pure (ligand-free) NPs. The biomedical application of such NPs is less studied than materials from other synthesis methods. The objective is to study the effect of pure magnetite NPs in the NaCl matrix obtained by EB PVD on hematological indicators, gases, electrolytes and parameters of iron metabolism in the blood of intact animals. The physical characteristics of NPs were studied using high-resolution transmission electron microscopy, scanning transmission electron microscopy, energy-dispersive X-ray spectroscopy mapping, electron energy-loss spectroscopy, selected area electron diffraction and fast Fourier transform. In vivo experiments were conducted on albino male rats, which were injected with solution of magnetite-sodium chloride NPs (1.35 mg Fe/kg). After 3 and 72 h, hematological parameters, blood gases, electrolytes, and serum iron were determined. The synthesized NPs had an average size of 11 nm. They were identified as magnetite, where polycrystals and single crystals were present. The absence of contamination in crystal boundaries, clear orientation and orderliness of atoms in crystals were established. The administration of NPs in the sodium chloride matrix to animals was characterized by a transient increase in the main indicators of red blood accompanied by an increase in the saturation of erythrocytes with hemoglobin and their mean volume after 3 h. It did not worsen blood gases and pH, but decreased blood Na+ content after 72 h. The investigated NPs caused changes in the parameters of serum iron characteristic to iron preparations, which after 3 h were smaller compared to the reference iron drug, and after 72 h—similar to it. More intense rapid effects on hematological parameters at lower serum iron indicate greater activity of the studied pure magnetite NPs obtained by EB PVD syntesis compared to the reference iron preparation.

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Synthesis of pure (ligandless) titanium nanoparticles by EB-PVD method

Cited by 4 publications

References 35 publications

Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

Assessment of Gold Nanoparticles Uptake in Tissues of Female Mice and Their Offspring Using Neutron Activation Analysis

Effect of pure (ligand-free) nanoparticles of magnetite in sodium chloride matrix on hematological indicators, blood gases, electrolytes and serum iron

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