Synthesis of pyrazoline fatty chain derivatives and its effects on melanoma cells

Antiqueira-Santos, Priscila; Teixeira, Wystan K. O.; Flores, Alex F. C.; Piovesan, Luciana A.; Nery, Luíz Eduardo; Votto, Ana Paula de Souza

doi:10.1016/j.bmcl.2021.127988

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…The drug is of great importance for skin cancer therapy; studies have shown that it induces apoptosis in tumor cells, which results in the reduction or elimination of the tumor. In conjunction with nanofiber systems, which exhibit similar properties to the natural fibrillar structure, hybrid systems could be used for the controlled release of drugs in the treatment of local anti-melanoma chemotherapy [ 65 , 96 ].…”

Section: Materials Used In Hybrid Systemsmentioning

confidence: 99%

Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems

et al. 2023

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Nanomedicine is a new discipline resulting from the combination of nanotechnology and biomedicine. Nanomedicine has contributed to the development of new and improved treatments, diagnoses, and therapies. In this field, nanoparticles have notable importance due to their unique properties and characteristics, which are useful in different applications, including tissue engineering, biomarkers, and drug delivery systems. Electrospinning is a versatile technique used to produce fibrous mats. The high surface area of the electrospun mats makes them suitable for applications in fields using nanoparticles. Electrospun mats are used for tissue engineering, wound dressing, water-treatment filters, biosensors, nanocomposites, medical implants, protective clothing materials, cosmetics, and drug delivery systems. The combination of nanoparticles with nanofibers creates hybrid systems that acquire properties that differ from their components’ characteristics. By utilizing nanoparticles and nanofibers composed of dissimilar polymers, the two synergize to improve the overall performance of electrospinning mats and nanoparticles. This review summarizes the hybrid systems of polymeric nanoparticles and polymeric nanofibers, critically analyzing how the combination improves the properties of the materials and contributes to the reduction of some disadvantages found in nanometric devices and systems.

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Section: Materials Used In Hybrid Systemsmentioning

confidence: 99%

Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems

et al. 2023

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“…Derivatives with antiviral, antimalarial, and anticancer activity are also known [26][27][28][29][30]. Thiosemicarbazides are often an initial compound for the synthesis of new active substances that include antibacterial and antifungal properties [31][32][33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

New Thiosemicarbazide Derivatives with Multidirectional Biological Action

Lasek,

Kosikowska,

Kołodziej

et al. 2024

Molecules

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Over the years, several new medicinal substances have been introduced for the treatment of diseases caused by bacteria and parasites. Unfortunately, due to the production of numerous defense mechanisms by microorganisms and parasites, they still pose a serious threat to humanity around the world. Therefore, laboratories all over the world are still working on finding new, effective methods of pharmacotherapy. This research work aimed to synthesize new compounds derived from 3-trifluoromethylbenzoic acid hydrazide and to determine their biological activity. The first stage of the research was to obtain seven new compounds, including six linear compounds and one derivative of 1,2,4-triazole. The PASS software was used to estimate the potential probabilities of biological activity of the newly obtained derivatives. Next, studies were carried out to determine the nematocidal potential of the compounds with the use of nematodes of the genus Rhabditis sp. and antibacterial activity using the ACCT standard strains. To determine the lack of cytotoxicity, tests were performed on two cell lines. Additionally, an antioxidant activity test was performed due to the importance of scavenging free radicals in infections with pathogenic microorganisms. The conducted research proved the anthelmintic and antibacterial potential of the newly obtained compounds. The most effective were two compounds with a 3-chlorophenyl substituent, both linear and cyclic derivatives. They demonstrated higher efficacy than the drugs used in treatment.

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“…The synthesis of azoles, especially pyrazoles and triazoles, has received great attention because they are often closely associated with other pharmacological properties of bioactive compounds. [1][2][3] In addition to this, the incorporation of fluorine atoms in organic molecules is of great interest because these derivatives are also present in many pharmaceuticals, agrochemicals and other task-specific materials. [4][5][6] For instance, these azoles act as COX-2 inhibitors (Celecoxib, Deracoxib and Mavacoxib), 7 succinate dehydrogenase inhibitors, 8 fungicidal agents against Fusarium graminearum, 9 and they have been applied in other applications as oxidizers and as energetic materials, 10 and in liquid crystals.…”

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confidence: 99%

Synthesis of Methylene-Bridged Trifluoromethyl Azoles Using 5-(1,2,3-Triazol-1-yl)enones

et al. 2021

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A protocol for synthesizing triazole-containing pyrazolines and pyrazoles selectively using trifluoromethylated 5-(1,2,3-triazol-1-yl)enones as starting materials, is reported. The selectivity of the reaction was controlled by the nature of the hydrazine or derivative used: free hydrazines furnished the 1,5-regiosiomer exclusively in yields up to 98%, whereas protected hydrazines provided the 1,3-regioisomer in yields up to 77%. To demonstrate the synthetic versatility of the triazole-based enone, reactions with other unsymmetrical dinucleophiles (hydroxylamine hydrochloride and S-methyl isothiourea sulfates) allowed the selective preparation of triazole-containing isoxazoline and pyrimidine rings.

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Synthesis of pyrazoline fatty chain derivatives and its effects on melanoma cells

Cited by 6 publications

References 35 publications

Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems

Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems

New Thiosemicarbazide Derivatives with Multidirectional Biological Action

Synthesis of Methylene-Bridged Trifluoromethyl Azoles Using 5-(1,2,3-Triazol-1-yl)enones

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