Synthesis of pyrrolidinone derivatives from aniline, an aldehyde and diethyl acetylenedicarboxylate in an ethanolic citric acid solution under ultrasound irradiation

7‐Aminonaphthalene‐1,3‐disulfonic acid‐functionalized magnetic Fe3O4 nanoparticles efficiently catalyse the one‐pot multi‐component synthesis of substituted 3‐pyrrolin‐2‐ones without using any other harmful organic reagents. High catalytic activity, ease of recovery, use of an external magnetic field and capability of being reused many times without significant loss of its catalytic activity are additional eco‐friendly properties of this catalytic system. Compared to other methods, our protocol has various advantages such as short reaction times, low catalyst loading, high yields, easy magnetic separation and reusability of the catalyst.

Section: Resultsmentioning

confidence: 99%

One‐pot synthesis of polysubstituted pyrrolidinones using novel magnetic nanoparticles as an efficient and reusable catalyst

Ghorbani‐Vaghei

Sarmast

Mahmoodi

2016

“…They are very interesting and occur in many natural and biologically active products, as well. In this regard, scholars are making great efforts to synthesize new bioactive N ‐heterocycles …”

Section: Introductionmentioning

confidence: 99%

An overview on the copper‐promoted synthesis of five‐membered heterocyclic systems

Shiri

2020

The development of novel approaches for the preparation of small‐sized heterocyclic products has remained an extremely attractive but challenging proposition. Copper has been known as one of the most applicable and significant transition metals utilized in the synthesis of organic products. A couple of factors such as high earth abundance and versatile catalysis resulted in the growth of copper‐promoted synthesis of five‐membered heterocyclic products. Utilizations such as making coins and electrical equipment express the importance of copper, as well. Here, a comprehensive overview of the copper‐catalyzed synthesis of five‐membered heterocyclic products is presented, focusing on the developments over the past 4 years.

“…[28][29][30] Easy magnetic separation of the MNPs-supported catalysts from the reaction mixtures enables convenient purification avoiding expensive centrifugation or conventional filtration methods. [42][43][44][45] Therefore, these reactions provide the scientists an efficient, time saving and atom economical approach to a wide variety of organic and bioorganic molecules including heterocyclic compounds. In recent years, magnetic Fe 3 O 4 nanoparticles have attracted much attention as privileged supports for immobilization of various catalysts due to their specific properties such as nontoxicity, easy preparation, low cost, good stability, and high surface-area.…”

Section: Introductionmentioning

confidence: 99%

Fe₃O₄‐supported Schiff‐base copper (II) complex: A valuable heterogeneous nanocatalyst for one‐pot synthesis of new pyrano[2,3‐b]pyridine‐3‐carboxamide derivatives

Mahmoudi‐GomYek

Azarifar

Ghaemi

et al. 2019

A novel Cu (II) Schiff-base complex immobilized on core-shell magnetic Fe 3 O 4 nanoparticles (Fe 3 O 4 @SPNC) was successfully designed and synthesized. The structural features of these nanoparticles were studied and confirmed by using various techniques including FT-IR spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive Xray spectroscopy (EDS), vibrating sample magnetometer (VSM), X-Ray diffraction (XRD), wavelength dispersive X-ray spectroscopy (WDX), and inductively coupled plasma (ICP). These newly synthesized nanoparticles have been used as efficient heterogeneous catalytic system for one-pot multicomponent synthesis of new pyrano[2,3-b]pyridine-3-carboxamide derivatives. Notably, the catalyst could be easily separated from the reaction mixture by using an external magnet and reused for several successive reaction runs with no significant loss of activity or copper leaching. The present protocol benefits from a hitherto unreported MNPs-immobilized Cu (II) Schiff-base complex as an efficient nanocatalyst for the synthesis of newly reported derivatives of pyrano[2,3-b] pyridine-3-carboxamide from one-pot multicomponent reactions.