One‐pot synthesis of polysubstituted pyrrolidinones using novel magnetic nanoparticles as an efficient and reusable catalyst

Abstract

7‐Aminonaphthalene‐1,3‐disulfonic acid‐functionalized magnetic Fe3O4 nanoparticles efficiently catalyse the one‐pot multi‐component synthesis of substituted 3‐pyrrolin‐2‐ones without using any other harmful organic reagents. High catalytic activity, ease of recovery, use of an external magnetic field and capability of being reused many times without significant loss of its catalytic activity are additional eco‐friendly properties of this catalytic system. Compared to other methods, our protocol has various advantages such as short reaction times, low catalyst loading, high yields, easy magnetic separation and reusability of the catalyst.

Fe3O4@SiO2@propyl‐ANDSA: A new catalyst for the synthesis of tetrazoloquinazolines

“…Thirdly, the Fe 3 O 4 @SiO 2 nanoparticles were coated by (3‐chloropropyl)‐triethoxysilane, yielding the chloro functionalized nanoparticles (Fe 3 O 4 @SiO 2 @Cl MNPs) . Finally, the Fe 3 O 4 @SiO 2 @Cl nanoparticles reacted with 7‐aminonaphthalene‐1,3‐disulfonic acid to yield Fe 3 O 4 @SiO 2 @Propyl–ANDSA . The acidic content of Fe 3 O 4 @SiO 2 @Propyl–ANDSA was characterized by determination of H + of the catalyst through back titration with NaOH (0/1 mol/L).…”

Green synthesis of new pyrimido[4,5‐d]pyrimidine derivatives using 7‐aminonaphthalene‐1,3‐disulfonic acid‐functionalized magnetic Fe3O4@SiO2 nanoparticles as catalyst

“…As illustrated in Scheme , preparation of catalyst followed with coating a layer of silica on the surface of the Fe 3 O 4 nanoparticles and then functionalization of the iron oxide with two sulfonic acid groups was achieved by treatment with tetraethyl orthosilicate [(EtO) 4 Si] and then with 3‐chloropropyltriethoxysilane, followed by ANDSA (Scheme ). Fe 3 O 4 @SiO 2 @Propyl‐ANDSA nanoparticles were characterized by FT‐IR, scanning electron microscopy, transmission electron microscopy (TEM), thermo‐gravimetric analysis (TGA), X‐ray powder diffraction, X‐ray photoelectron spectroscopy, energy‐dispersive X‐ray spectroscopy (EDX), vibrating sample magnetometer (VSM) and ion exchange pH‐analysis . In order to determine the amount of ANDSA loaded on the surface of fe3o4@sio2@Propyl, we measured the percentage of sulfur in Fe 3 O 4 @SiO 2 @Propyl‐ANDSA and Fe 3 O 4 @SiO 2 @Propyl, with elemental analysis.…”

“…Fe 3 O 4 @SiO 2 @Propyl-ANDSA nanoparticles were characterized by FT-IR, scanning electron microscopy, transmission electron microscopy (TEM), thermo-gravimetric analysis (TGA), X-ray powder diffraction, X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy (EDX), vibrating sample magnetometer (VSM) and ion exchange pH-analysis. [21] In order to determine the amount of ANDSA loaded on the surface of fe3o4@sio2@Propyl, we measured the percentage of sulfur in Fe 3 O 4 @SiO 2 @Propyl-ANDSA and Fe 3 O 4 @SiO 2 @Propyl, with elemental analysis. Using the obtained data (Tables S1 and S2), the amount of ANDSA loaded on the Fe 3 O 4 @SiO 2 @Propyl was calculated as 6.48%.…”

CoFe2O4@SiO2‐PA‐CC‐Guanidine MNPs as an Efficient Catalyst for the One‐Pot, Four‐Component Synthesis of Pyrazolopyranopyrimidines

“…[16,17] In the past decades, the use of nanoparticles [18] as heterogeneous catalysts in the organic synthesis was increased. Activity of heterogeneous catalysts [19] in compare to homogeneous catalysts [20] is less but extraction of these catalysts from the reaction mixture is very comfort. Nanoparticles have features of homogeneous and heterogeneous catalysts.…”