Synthesis of quercetin-encapsulated alginate beads with their antioxidant and release kinetic studies

Özbilenler, Cahit; Altundağ, Ergül Mutlu; Gazi, Mustafa

doi:10.1080/10601325.2020.1817756

Cited by 21 publications

(16 citation statements)

References 43 publications

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“…Among them, the samples loaded with drug containing 0.1 g of Ch (P1, P2, and P3) present a higher swelling index than those containing 0.2 g of Ch (P5, P6, and P7), as can be seen from data reported in Figures 6 and 7. As a consequence of the increase in the swelling index, the drug release rate in the in vitro test also increases, due to the hydrophilicity of the polymer matrix, which has the ability to absorb water over time, protecting in this way QUE from enzymatic degradation in the gastrointestinal tract [39].…”

Section: Swelling Index (Idxswl (%)) Study Resultsmentioning

confidence: 99%

Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin

et al. 2022

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The aim of this paper was to formulate microspheres based on biodegradable polymers (chitosan and sodium alginate), using the complex coacervation technique. Subsequently, the prepared microspheres were loaded with quercetin (QUE), a pharmacological active ingredient insoluble in water and unstable to light, temperature and air. After preparation, the loaded microspheres underwent several studies for physical chemical characterization (performed by scanning electron microscopy—SEM, laser 3D scanning, and thermal analysis—TA). Furthermore, they were analyzed in order to obtain information regarding swelling index, drug entrapment, and in vitro release capacity. The obtained experimental data demonstrated 86.07% entrapment of QUE into the microspheres, in the case of the one with the highest Ch concentration. Additionally, it was proved that such systems allow the controlled release of the active drug over 24 h at the intestinal level. SEM micrographs proved that the prepared microspheres have a wrinkled surface, with compact structures and a large number of folds. On the basis of the TA analysis, it was concluded that the obtained microspheres were thermally stable, facilitating their usage at normal physiological temperatures as drug delivery systems.

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Section: Swelling Index (Idxswl (%)) Study Resultsmentioning

confidence: 99%

Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin

et al. 2022

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“…Alginate cryogel cross-linked with Ca 2+ [19] Ionic cryotropic gelation of pectin-chitosan [20] Freezing-thawing cycle PVA-gelatin cryogel; hydrogen bonding, formation of crystallites of PVA [21] Agarose cryogel, intramolecular and intermolecular hydrogen bonding [22] Chitosan cryogel, formation of crystallites composed of D-glucosamine and N-acetylglucosamine units [23,24] Chemical cross-linking Reaction between the functional groups of polymer and cross-linker or polymer-polymer Condensation of an amine with the carbonyl group, formation of Schiff bases; chitosan and gelatin cross-linked with glutaraldehyde.…”

Section: Ionic Interactionmentioning

confidence: 99%

“…Electron-beam initiated cross-linking reaction; dextran, hyaluronan [35][36][37] Photo-cross-linking UV photo-cross-linking; hyaluronic acid, dextran [38,39] An example of non-covalent ionic-type cross-linking is the preparation of ionic cryogels as a result of the growth of metal-polymer-coordinated complexes and electrostatic interactions between oppositely charged groups of chitosan and metal ions such as PdCl 4 2− , PtBr 4 2− and PtCl 4 2− at sub-zero temperatures [40,41]. Alginate-based cryogel can be obtained by introducing ionic links between anionic polysaccharide macromers with divalent cations such as Ca 2+ [19].…”

Section: Ionic Interactionmentioning

confidence: 99%

“…Facilitates cancer cell invasion, migration and proliferation allowing for comprehensive characteristic of tumor cell behavior and testing the activity of anticancer drugs [29] Hyaluronic acid-PEG Immobilized biomimetic ligands offer control over cellular response resulting in enhanced spreading with RGD and formation of 3D cell spheroids with IKVAV [161] HEMA-Alginate-Gelatin 3D culturing of prostate cancer cells and spheroids to study their progression and behavior [188] Poly(ethylene glycol) diacrylate and type I collagen semi-interpenetrating polymer network cryogels Tunable off-the-shelf platforms for 3D cancer cell [112] Drug delivery HEMA-Gelatin pH-responsive release of doxorubicin with increased rate in more acidic conditions mimicking tumor environment [30] Inulin cryogel Release of amoxicillin trihydrate [85] Alginate beads Release of quercetin as antioxidant [19] Chitosan, hydroxyapatite, heparin, and polyvinyl alcohol composite Release of bone morphogenic protein 2 and support of the differentiation of rat bone marrow mesenchymal stem cells.…”

Section: Gelatinmentioning

confidence: 99%

“…Composed of β-D-mannuronate and α-L-guluronate monomers, this copolymer is often ionically cross-linked with cations, such as Ca 2+ . Alginate hydrogel beads cross-linked with Ca 2+ were subjected to three freeze-thaw processes to obtain cryogels [ 19 ]. These cryogels were tested for the release of quercetin, the bioactive flavonoid, encapsulated in the beads.…”

Section: Biodegradable Cryogelsmentioning

confidence: 99%

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Design and Assessment of Biodegradable Macroporous Cryogels as Advanced Tissue Engineering and Drug Carrying Materials

Zoughaib

Yergeshov

2021

Gels

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Cryogels obtained by the cryotropic gelation process are macroporous hydrogels with a well-developed system of interconnected pores and shape memory. There have been significant recent advancements in our understanding of the cryotropic gelation process, and in the relationship between components, their structure and the application of the cryogels obtained. As cryogels are one of the most promising hydrogel-based biomaterials, and this field has been advancing rapidly, this review focuses on the design of biodegradable cryogels as advanced biomaterials for drug delivery and tissue engineering. The selection of a biodegradable polymer is key to the development of modern biomaterials that mimic the biological environment and the properties of artificial tissue, and are at the same time capable of being safely degraded/metabolized without any side effects. The range of biodegradable polymers utilized for cryogel formation is overviewed, including biopolymers, synthetic polymers, polymer blends, and composites. The paper discusses a cryotropic gelation method as a tool for synthesis of hydrogel materials with large, interconnected pores and mechanical, physical, chemical and biological properties, adapted for targeted biomedical applications. The effect of the composition, cross-linker, freezing conditions, and the nature of the polymer on the morphology, mechanical properties and biodegradation of cryogels is discussed. The biodegradation of cryogels and its dependence on their production and composition is overviewed. Selected representative biomedical applications demonstrate how cryogel-based materials have been used in drug delivery, tissue engineering, regenerative medicine, cancer research, and sensing.

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Alginate beads loaded with rambutan extract: characterization and stability during in vitro gastrointestinal digestion

Aksornsri,

Peanparkdee

2024

J Sci Food Agric

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BackgroundThe fallen young rambutan fruit are an underrated agricultural‐wastes which may contain several bioactive compounds. In this study, the fallen young rambutan fruit was assessed regarding their phenolic contents and antioxidant activities. In order to expand its utilization, rambutan extract‐loaded hydrogel beads were developed by basic spherification technique using sodium alginate. The effect of ratios of polymer and extract and different calcium sources were evaluated. The recovery of bioactive compounds from hydrogel beads were determined using in vitro gastrointestinal digestion models.ResultsA 50% (v/v) of ethanol yielded rambutan extract with high chemical properties. The production of hydrogel beads using ratio of 1:3 with calcium lactate (CL) provided the highest percent of production yield of 122.94%. The hydrogel beads developed using the ratio of 1:3 with combination of calcium lactate and calcium chloride (CC) showed high recovery of phenolic compounds and their antioxidant activity after simulated intestinal digestion, which were greater values compared to unencapsulated extract.ConclusionThis finding demonstrates that the ratio of wall material to rambutan extract and the calcium sources influence the physical properties, chemical properties, and in vitro gastrointestinal digestion stability of alginate beads. The obtained hydrogel beads may potential application in the food or pharmaceutical industries.This article is protected by copyright. All rights reserved.

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Synthesis of quercetin-encapsulated alginate beads with their antioxidant and release kinetic studies

Cited by 21 publications

References 43 publications

Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin

Preparation and Characterization of Chitosan-Alginate Microspheres Loaded with Quercetin

Design and Assessment of Biodegradable Macroporous Cryogels as Advanced Tissue Engineering and Drug Carrying Materials

Alginate beads loaded with rambutan extract: characterization and stability during in vitro gastrointestinal digestion

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