Synthesis of Quinoline and Quinolin-2(1H)-one Derivatives via Nickel Boride Promoted Reductive Cyclization

Abstract

A mild and efficient approach for the synthesis of diversely substituted quinoline and quinoline-2-one derivatives has been disclosed. In situ-generated nickel boride was proved to be an effective promoter of the reductive cyclization reaction. Broad substrate scope, mild reaction condition, consistent yield and wide range of functional group tolerance are the other notable features of the newly discovered reaction. A large number of quinoline and quinoline -2-one derivatives may be prepared from milligram to multigram scale employing this intramolecular reductive cyclization protocol.