Synthesis of Related Compounds of Thiosemicarbazide. VIII. : 5-Mercapto-and 5-Amino-s-triazolo [3, 4-b] [1, 3, 4] thiadiazoles.

Kanaoka, Matao; Okuda, Takako; Shiho, Den-itsu

doi:10.1248/yakushi1947.87.2_119

Cited by 7 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yields and elemental analyses of the compounds are listed in ( 8) 0.3316(9) 0.2457 ( 7) 0.4486 ( 7) 0.35685(8) 0.0745(2) 0.3083 (7) 0.1644 (7) 0.5325 (7) 0.7456 (8) (7) 0.0662( 6) 0.0910 (7) 0.1338 (6) 0.0882 (6) 0.37836(7) 3.28(2) -0.0370(2) 4.89(6) 0.2639 (6) 3.7(2) 0.3061 (6) 4.2(2) 0.3065 (6) 3.6(2) 0.2624 (7) 4.9(2) 0.1953 (7) 5.7(3) 0.1714 (7) 6.2(3) 0.2174 (8) 6.5(3) 0.2842 (7) 4.9(2) 0.4938 (6) 3.5(2) 0.5166 (7) 5.7(2) 0.6017 (8) 7.3(3) 0.6623 ( 8) 7.6(4) 0.6389 (8) 7.1(4) 0.5538 (7) 4.8(2) 0.4314 (6) 3.9(2) 0.5347 (7) 4.9(2) 0.5693 (8) 6.2(3) 0.5064 ( 8) 5.8( 3) 0.4035 ( 8) 5.8( 3) 0.3673 (7) 4.8(2) 0.2194 (6) 4.2(2) 0.2704 (8) 5.6(3) 0.2299 (9) 8.1(3) 0.1391 (9) 8.5(4) 0.0860 ( 9) 8.6( 4) 0.1249 (7) 6.5(3) 0.1245 (6) 3.9(2) 0.1827 (7) 5.9(2) 0.1687 (8) 7.5(3) 0.1036 (8) 8.6(3) 0.0455 (8) 7.4(3) 0.0584 (7) 5.3(3) 0.2 1 36 ( 6) 3.6( 2) O.2O40 ( 5) 4.4(2) 0.11 l6 (5) 4.1(2) O.0700 ( 6) 3. 6( 2) 0.1351 (5) 3.5 (2) "Anisotropically refined atoms are given in the form...…”

Section: Resultsmentioning

confidence: 99%

Synthesis of 1‐triphenylgermylpropiono‐4‐substituted semicarbazides, thiosemicarbazides and their heterocyclic derivatives

Chen

1995

Applied Organom Chemis

View full text Add to dashboard Cite

Twenty‐one new organogermanium compounds with the formulae Ph3GeCHR1CH2CONHNHC(X)NHR2 (1) (R1=H, Ph; = Ph, p‐CH3Ph, O‐CH3Ph, p‐ClPh, COPh, X = S, O) and (R1 = H, Ph; R2 = Ph, p‐CH3Ph, o‐CH3Ph, p‐ClPh; X=S, O) were synthesized and characterized by elemental analysis, 1H NMR, IR, MS and X‐ray diffraction techniques. Compounds l were prepared by the reactions of Ph3GeCHR1CH2CONHNH2 with R2NCX in chloroform in 77‐94% yields, and 2 were obtained by refluxing l with sodium hydroxide (8%) with yields of 55‐94%.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis of 1‐triphenylgermylpropiono‐4‐substituted semicarbazides, thiosemicarbazides and their heterocyclic derivatives

Chen

1995

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

5,5‐System With a Bridgehead Nitrogen Atom

Paolini¹

1977

Chemistry of Heterocyclic Compounds: A Series of Monographs

View full text Add to dashboard Cite

Synthesis of heterocycles. Part VII Synthesis and antimicrobial activity of some 7H‐s‐triazolo[3,4‐b][1,3,4]thiadiazine and s‐triazolo[3,4‐b][1,3,4]thiadiazole derivatives

Eweiss

Bahajaj

1987

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

The cyclization of 4‐amino‐5‐aryl‐3‐cyanomethylthio‐1,2,4‐triazoles II in the presence of concentrated sulfuric acid yields 7H‐6‐amino‐s‐triazolo[3,4‐b][1,3,4]thiadiazines III. Cyclization of 4‐amino‐5‐aryl‐1,2,4‐tria‐zole‐3‐thiones I with phenacyl chloride yields 7H‐3‐aryl‐6‐phenyl‐s‐triazolo[3,4‐b][1,3,4]thiadiazines IV. Similarly, compounds I condensed with cyanogen bromide, phenyl isothiocyanate and carbon disulfide to give the corresponding cyclized products 6‐amino‐3‐aryl‐s‐triazolo[3,4‐b][1,3,4]thiadiazoles V, 3‐aryl‐6‐phenyl‐amino‐s‐triazolo[3,4‐b][1,3,4]thiadiazoles VI and 3‐aryl‐striazolo[3,4‐b][1,3,4]thiadiazol‐6(5H)thiones VII, respectively. Also in the presence of phosphoryl chloride, compounds I underwent cyclization with monocarbo‐xylic acids and oxalic acid to 3,6‐diaryl‐s‐triazolo[3,4‐b][1,3,4]thiadiazole VIII and 6,6′‐bis(3‐aryl‐s‐triazolo‐[3,4‐b][1,3,4]thiadiazoles) IX. The above compounds were screened for their antimicrobial activity.

show abstract

Synthesis of Related Compounds of Thiosemicarbazide. VIII. : 5-Mercapto-and 5-Amino-s-triazolo [3, 4-b] [1, 3, 4] thiadiazoles.

Cited by 7 publications

References 0 publications

Synthesis of 1‐triphenylgermylpropiono‐4‐substituted semicarbazides, thiosemicarbazides and their heterocyclic derivatives

Synthesis of 1‐triphenylgermylpropiono‐4‐substituted semicarbazides, thiosemicarbazides and their heterocyclic derivatives

5,5‐System With a Bridgehead Nitrogen Atom

Synthesis of heterocycles. Part VII Synthesis and antimicrobial activity of some 7H‐s‐triazolo[3,4‐b][1,3,4]thiadiazine and s‐triazolo[3,4‐b][1,3,4]thiadiazole derivatives

Contact Info

Product

Resources

About