Synthesis of Rough Colloidal SU-8 Rods and Bananas via Nanoprecipitation

Fernández‐Rico, Carla; Urbach, Jeffrey S.; Dullens, Roel P. A.

doi:10.1021/acs.langmuir.0c03361

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…Curved and straight microrods were fabricated following an adapted protocol for the formation of SU-8 rods, ,, based on earlier work from Alargova et al In a typical synthesis, 110 mL of glycerol was added to a 250 mL glass beaker. A mixer (Ika Werk RW-20, Janke and Kunkel), equipped with an impeller of 4 cm in diameter, was positioned 2 cm above the bottom of the beaker and set to 2000 rpm.…”

Section: Methods/experimental Sectionmentioning

confidence: 99%

Role of Shape in Particle-Lipid Membrane Interactions: From Surfing to Full Engulfment

van der Ham,

Agudo-Canalejo,

Vutukuri

2024

ACS Nano

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Understanding and manipulating the interactions between foreign bodies and cell membranes during endo-and phagocytosis is of paramount importance, not only for the fate of living cells but also for numerous biomedical applications. This study aims to elucidate the role of variables such as anisotropic particle shape, curvature, orientation, membrane tension, and adhesive strength in this essential process using a minimal experimental biomimetic system comprising giant unilamellar vesicles and rod-like particles with different curvatures and aspect ratios. We find that the particle wrapping process is dictated by the balance between the elastic free energy penalty and adhesion free energy gain, leading to two distinct engulfment pathways, tip-first and side-first, emphasizing the significance of the particle orientation in determining the pathway. Moreover, our experimental results are consistent with theoretical predictions in a state diagram, showcasing how to control the wrapping pathway from surfing to partial to complete wrapping by the interplay between membrane tension and adhesive strength. At moderate particle concentrations, we observed the formation of rod clusters, which exhibited cooperative and sequential wrapping. Our study contributes to a comprehensive understanding of the mechanistic intricacies of endocytosis by highlighting how the interplay between the anisotropic particle shape, curvature, orientation, membrane tension, and adhesive strength can influence the engulfment pathway.

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Section: Methods/experimental Sectionmentioning

confidence: 99%

Role of Shape in Particle-Lipid Membrane Interactions: From Surfing to Full Engulfment

van der Ham,

Agudo-Canalejo,

Vutukuri

2024

ACS Nano

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“…Compared to the frequently-used smooth particles, rough colloids exhibit complex capillary interactions and wetting properties at liquid interfaces, which is particularly critical for Pickering emulsions. [11][12][13] Previously, Isa et.al. reported that interfacial rough colloids can impose metastable contact angles, which makes them "universal emulsifiers" for the stabilization of both oil-in-water (O/W) and water-in-oil (W/O) emulsions, as well as the inversion between these two systems.…”

Section: Introductionmentioning

confidence: 99%

Continuous Emulsion Channels Achieved by Controlling the Aqueous–Oil Interface Solely with Rough Colloids

Chen,

Kato,

Dai

et al. 2023

Adv Funct Materials

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As a new class of soft materials, continuous emulsion channels have been successfully stabilized solely by rough colloids, which exhibit unique capability in sterically controlling liquid–liquid interfaces. Once jammed at the interface, the roughness‐enhanced frictions can slow down the dynamics of phase separation, and the interlocking behaviors would constrain their relative motions and generate force structures that provide mechanical support for the created emulsions. Ethanol is used to ensure the particles’ absorption, whose migration can modify the interfacial tension, and increase the solubility of active ingredients (e.g., curcumin). Applying rough colloids in ethanol‐containing systems opens new pathways toward the generation of novel structures and materials, where the parallel but separate functionalities provided by various phases demonstrate wide‐ranging applications, especially in delivery systems with variably soluble components.

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“…In it, polymer solution droplets are deformed and elongated by the shear force in the antisolvent and then solidified into rod-like particles by solvent attrition, exchange, and evaporation. For instance, the shear-driven emulsification solvent attrition technique for the synthesis of SU8 rods, first reported by Velev and colleagues, is a simple method for the rapid, convenient, and large-scale production of synthetic polymer microrods. ,, This method has been widely applied for the preparation of other types of rod-like particles, including cellulose rods, ,, polystyrene nanofibers, poly(ethylene glycol)- b -polystyrene, and molecular paraffin wax microrods . Shear-driven emulsification solvent attrition requires a viscous dispersion medium to achieve viscous shear to elongate the droplets of the polymer solution.…”

mentioning

confidence: 99%

Facile Fabrication of Starch-Based Microrods by Shear-Assisted Antisolvent-Induced Nanoprecipitation and Solidification

Zhang

Pei

et al. 2022

ACS Macro Lett.

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Rod-like particles have attracted increasing attention because of their unique shape-dependent properties, which enable their superior performance compared to their isotropic counterparts. Thus, rod-like particles have potential applications in many fields, especially in biomedicine. However, the fabrication of uniform rod-like particles is challenging because of the principle of interfacial energy minimization. Herein, we present a facile, rapid, and cost-effective strategy for preparing starch-based microrods with tunable aspect ratios via shear-assisted antisolvent-induced nanoprecipitation and solidification. The preformed spherical particles swollen by the mixed solvent were elongated by the shear force and solidified in rod-like shape by antisolvent induction. The resulting starch-based microrods can encapsulate hydrophobic active substances and be modified with functional groups, indicating their potential applications as drug carriers and biologically active materials. The formation mechanism of the starch-based microrods discovered in this study provides a new perspective on the fabrication of rod-like polymer particles.

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Synthesis of Rough Colloidal SU-8 Rods and Bananas via Nanoprecipitation

Cited by 7 publications

References 31 publications

Role of Shape in Particle-Lipid Membrane Interactions: From Surfing to Full Engulfment

Role of Shape in Particle-Lipid Membrane Interactions: From Surfing to Full Engulfment

Continuous Emulsion Channels Achieved by Controlling the Aqueous–Oil Interface Solely with Rough Colloids

Facile Fabrication of Starch-Based Microrods by Shear-Assisted Antisolvent-Induced Nanoprecipitation and Solidification

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