Synthesis of Silica Supported Perchloric Acid Nanoparticles (HClO₄–SiO₂ NPs): Efficient Synthesis of Biscoumarin Derivatives in Water

Abstract

Reaction between aromatic aldehydes or phenylglyoxals and 4-hydroxycoumarin catalysed by silica supported perchloric acid nanoparticles (HClO 4 -SiO 2 NPs) in water at reflux provided a simple and efficient route for the synthesis of biscoumarin derivatives in high yields.

Effective Synthesis and Biological Evaluation of Dicoumarols: Preparation, Characterization, and Docking Studies

“…Dicoumarols are obtained through a straightforward condensation reaction between 4-hydroxycoumarin and aldehydes using various catalysts and media. There are numerous reported methods for synthesizing these compounds, including the use of catalysts like sodium dodecyl sulfate, ionic liquids with Lewis acid/Bronsted acid sites, molecular iodine, Ce 2 (SO 4 ) 4 H 2 O, p -dodecyl benzenesulfonic acid/piperidine, SO 3 H functionalized ionic liquids, sulfated titania, and nano-silica catalysts. − Numerous synthetic techniques utilizing 4-hydroxycoumarin have recently been developed for the synthesis of biscoumarins in aqueous conditions, in response to the growing public concern about the environment. Despite their effectiveness and environmental friendliness, these techniques require catalysts, such as TEBA and I 2 , and have long reaction times.…”

Nano-sawdust–BF3 as a new, cheap, and effective nano catalyst for one-pot synthesis of 2-amino benzo[h]chromene derivatives

“…Therefore, the development of a simple, mild, and efficient method is still needed. In continuation of our previous research on the use of solid nano catalyst in organic synthesis [14][15][16][17][18][19][20][21], the nano-sawdust-BF 3 as a new catalyst has been applied for the synthesis of 2-amino benzo[h]chromene derivatives.…”

“…In recent years, there has been growing interest in finding inexpensive and effective solid acid nano catalyst such as nanocrystalline TiO 2 -HClO 4 [7], nano-TiCl 4 ÁSiO 2 [8][9][10] nano-SnCl 4 ÁSiO 2 [11,12] nano-BF 3 ÁSiO 2 [13][14][15] HClO 4 -SiO 2 nanoparticles [16] and nano-silica sulfuric acid [17][18][19][20][21][22][23]. Sawdust is one of the most common materials that used for various chemical industries such as removing pollutants from water [24], the color removal from textile industry [25], the removing cationic, anionic, and disperse dyes from aqueous solution [26] and the CuFe 2 O 4 /sawdust composite was used for removal of cyanine acid blue from aqueous solution [27].…”