Synthesis of Silver Nanocomposite Based on Carboxymethyl Cellulose: Antibacterial, Antifungal and Anticancer Activities

Abstract

Traditional cancer treatments include surgery, radiation, and chemotherapy. According to medical sources, chemotherapy is still the primary method for curing or treating cancer today and has been a major contributor to the recent decline in cancer mortality. Nanocomposites based on polymers and metal nanoparticles have recently received the attention of researchers. In the current study, a nanocomposite was fabricated based on carboxymethyl cellulose and silver nanoparticles (CMC-AgNPs) and their antibacterial, antifungal, and anticancer activities were evaluated. The antibacterial results revealed that CMC-AgNPs have promising antibacterial activity against Gram-negative (Klebsiella oxytoca and Escherichia coli) and Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus). Moreover, CMC-AgNPs exhibited antifungal activity against filamentous fungi such as Aspergillus fumigatus, A. niger, and A. terreus. Concerning the HepG2 hepatocellular cancer cell line, the lowest IC50 values (7.9 ± 0.41 µg/mL) were recorded for CMC-AgNPs, suggesting a strong cytotoxic effect on liver cancer cells. As a result, our findings suggest that the antitumor effect of these CMC-Ag nanoparticles is due to the induction of apoptosis and necrosis in hepatic cancer cells via increased caspase-8 and -9 activities and diminished levels of VEGFR-2. In conclusion, CMC-AgNPs exhibited antibacterial, antifungal, and anticancer activities, which can be used in the pharmaceutical and medical fields.

Green Synthesis and Antibacterial Activity of Ag/Fe2O3 Nanocomposite Using Buddleja lindleyana Extract

“…Thus, new active and safe antimicrobial agents are required. Because nanomaterials have antibacterial capabilities, they have recently received attention [ 74 , 75 ]. According to Figure 7 , the well diffusion technique was used in this investigation to evaluate the Ag/Fe 2 O 3 nanocomposite’s antibacterial efficacy against human bacterial pathogens ( S aureus , E. coli , B subtilis , and P. aeruginosa ).…”

Antifungal Activity of Biosynthesized Silver Nanoparticles (AgNPs) against Aspergilli Causing Aspergillosis: Ultrastructure Study

“…For successful control and treatment of fungal diseases, recent strategies including the production of nanoparticle-based medicines have been addressed [ 13 ]. Nanoparticles, such as silver nanoparticles (AgNPs), have been used for a long time as antimicrobial agents and are highly effective against fungal pathogens [ 14 , 15 , 16 , 17 , 18 ]. AgNPs work through a variety of mechanisms, including binding to phosphate groups in DNA [ 19 ] and plasma membrane interactions that cause protons to diffuse and cause cell death [ 20 ].…”

Mycosynthesis of Silica Nanoparticles Using Aspergillus niger: Control of Alternaria solani Causing Early Blight Disease, Induction of Innate Immunity and Reducing of Oxidative Stress in Eggplant

“…The fabrication of nanomaterials is one of nanotechnology’s most challenging and rapidly expanding sectors [ 24 ]. Nanoparticle synthesis can be accomplished through physical, chemical, or biological methods [ 25 , 26 , 27 , 28 , 29 ]. The employment of biological mass, such as bacteria, fungus, yeast, plant extract or biomass, and algal extract or biomass, is an alternative to conventional methods for the ecofriendly, healthier, faster, and less expensive synthesis of nanoparticles [ 30 , 31 , 32 , 33 ].…”