Synthesis of some bioactive 2-bromo-5-methoxy-N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives

Synthesis and antitumor activity of (4-hydroxyphenyl)[5-substituted alkyl/aryl)-2-thioxo-1,3,4-thiadiazol-3-yl]methanone and [(3,4-disubstituted)-1,3-thiazol-2ylidene]-4-hydroxybenzohydrazide

“…They have become drugs of immense importance and having a variety of biological activities such antitumor (Xia et al, 2007;Vijaya et al, 2007), antianginal (Abadi and Eissa, 2003), antitubercular (Bonde and Gaikwad, 2004;Joshi et al, 2008), antihypertensive (Bhandari et al, 2009;Raparti et al, 2009), MAO enzyme inhibitor (Ke et al, 2008), antibacterial (Joshi et al, 2008. Since the p-hydroxybenzohydrazide, thiadiazole, and thiazolin (Xia et al, 2007;Vijaya et al, 2007) moieties were reported for their anticancer properties, the newly synthesized compounds may show similar pharmacological profile to classical anticancer drugs.…”

“…p-Hydroxybenzohydrazide with thiazolin and thiadiazole moieties may be a proved perspective scaffolds for design of anticancer drugs. The heterocyclic benzohydrazides constitute an important class of biologically active molecules which have attracted attention of medicinal chemists due to their wide range of pharmacological properties and their potential application as antitumor, antineoplastic, antiviral, and antiinflammatory agents (Xia et al, 2007;Vijaya et al, 2007). On the other hand, it is well known that thiazoline and thiadiazole derivatives have a great biological relevance; these compounds carry out diverse biological functions, being present in a number of biological systems involving several biochemist reactions of physiological relevance.…”

Synthesis, Antihypertensive Activity, and 3D‐QSAR Studies of Some New p‐Hydroxybenzohydrazide Derivatives

“…Hypertension is recognized as a major risk factor in a human patient with cerebral hemorrhage and heart and renal disease; therefore, diagnosis of hypertension is carried out by measuring blood pressure on a regular basis [5][6][7]. p-Hydroxybenzohydrazide analogs seem to be suitable parent compounds from which a variety of biological activities are reported such as antitumor [8,9], anti-anginal [10], antitubercular [11,12], antihypertensive [13,14], MAO (monoamine oxidase) enzyme inhibitor [15], antibacterial [16], etc. Discovering three-dimensional pharmacophores which can explain the activity of a series of ligands is one of the most significant contributions of computational chemistry to drug discovery [16].…”

A comparative study on 2-(2-benzylidenehydrazinyl)-4-(3-methyl-3-phenylcyclobutyl) thiazole : X-ray, HF and DFT studies

“…The chemistry of aminothiazoles and their derivatives has attracted the attention of chemists, because they exhibit important biological activity in medicinal chemistry [5]. Thiazole derivatives exhibit different pharmaceutical properties such as anticancer [6,7], anticonvulsant [8], antipsychoticlike [9], antibacterial, antifungal [10,11], antitubercular [12], antimicrobial [13], analgesic and antiinflammatory [14] activities.…”