Synthesis of some cyclooctane-based pyrazines and quinoxalines

Alamdari, M; Helliwell, M.; Baradarani, Mehdi M.; Joule, J. A.

doi:10.3998/ark.5550190.0009.e17

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…mp > 300 o C. 1 H NMR (CDCl3 + CF3CO2H) δ 3.79 (t, J 6.9 Hz, 4H, 2 equivalent CH2), 3.96 (t, J 6.9 Hz, 4H, 2 equivalent CH2), 8.08 (dd, J1 6.6, J2 3.3 Hz, 2H, aromatic), 8.24 (dd, J1 6.6, J2 3.3 Hz, 2H, aromatic). 13 (12). 5-Cyclooctene-1,2-dione (1.00 g, 7.25 mmol), 1,2-diaminomaleonitrile (0.78 g, 7.24 mmol), and acetic acid (18 ml) were heated on the steam bath for 1 h. Water (ca.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of some cyclooctane-based pyrazines and quinoxalines. Part 2

alamdari¹

2022

Arkivoc

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The reaction of 5-cyclooctene-1,2-dione with 1,2-diaminomaleonitrile, produces 5,6,9,10-tetrahydrocycloocta[b]pyrazine-2,3-dicarbonitrile which was easily oxidized cleanly, under heterogeneous conditions by a combination of KMnO4, CuSO4•5H2O, t-BuOH in CH2Cl2 and water, to give 7-hydroxy-8-oxo-5,6,7,8,9,10hexahydrocycloocta[b]pyrazine-2,3-dicarbonitrile. This 2-hydroxy-ketone undergoes cyclocondensation with 1,2-diamines in hot acid acetic to furnish cyclooctane products with quinoxaline or pyrazine rings in a linear array, in good yields,

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Section: Methodsmentioning

confidence: 99%

Synthesis of some cyclooctane-based pyrazines and quinoxalines. Part 2

alamdari¹

2022

Arkivoc

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“…Cyclooctanes are a kind of saturated hydrocarbons. For many years, chemists have paid a lot of attention to their derivatives [30][31][32][33]. These derivatives are seen and used in drug synthesis, combustion kinetics, organic synthesis, etc.…”

Section: Methodsmentioning

confidence: 99%

“…For example, the osmium-catalysed bis-dihydroxylation of 1,5-cyclooctadiene has utilized cyclooctane 1, 2, 5, 6 tetrol [33]. Alamdari et al [30] considered the combination of some cyclooctanebased quinoxaline pyrazines. These molecular-like graphs [34,35] are geometric graphs (finite two-connected) bounded by a quadrangles of side length one and a regular octagon.…”

Section: Methodsmentioning

confidence: 99%

Expected Values of Some Molecular Descriptors in Random Cyclooctane Chains

Raza

Imran

2021

Symmetry

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The modified second Zagreb index, symmetric difference index, inverse symmetric index, and augmented Zagreb index are among the molecular descriptors which have good correlations with some physicochemical properties (such as formation heat, total surface area, etc.) of chemical compounds. By a random cyclooctane chain, we mean a molecular graph of a saturated hydrocarbon containing at least two rings such that all rings are cyclooctane, every ring is joint with at most two other rings through a single bond, and exactly two rings are joint with one other ring. In this article, our main purpose is to determine the expected values of the aforementioned molecular descriptors of random cyclooctane chains explicitly. We also make comparisons in the form of explicit formulae and numerical tables consisting of the expected values of the considered descriptors of random cyclooctane chains. Moreover, we outline the graphical profiles of these comparisons among the mentioned descriptors.

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“…In recent years, a set of macrocyclic aromatic hydrocarbons have attracted the interest of research scholars [16][17][18], which are known as cyclooctanes and their derivatives. For instance, the synthesis of a number of cyclooctyl pyrazines and quinoxazines has been found by Alamdari et al [16] has found. The reader can also refer to [18] for more information.…”

Section: * Corresponding Authormentioning

confidence: 99%

The expected values and limiting behaviours for the Gutman index, Schultz index, multiplicative degree-Kirchhoff index and additive degree-kirchhoff index of a random cyclooctane chain

Liu¹,

Gu²,

Wang³

2022

Preprint

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In this paper, we first introduce the explicit analytical formulas for the expected values of the Gutman and Schultz indices for a random cyclooctane chain COC n . Meanwhile, the explicit formulas of the variances of the Gutman and Schultz indices for a random cyclooctane chain are determined and we prove these two indices are asymptotically subject to normal distribution. Furthermore, we are surprised to find the variances of Kf * (COC n ) and Kf + (COC n ) for a random cyclooctane chain based on the known results of others' paper and they are asymptotically subject to normal distribution.

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Synthesis of some cyclooctane-based pyrazines and quinoxalines

Abstract: cis,cis-1,5-Cyclooctadiene is the starting point for the synthesis of quinoxaline-and pyrazinecontaining heterocycles with three, four or five rings in linear arrays with a central eightmembered carbocyclic ring.

Cited by 8 publications

References 9 publications

Synthesis of some cyclooctane-based pyrazines and quinoxalines. Part 2

Synthesis of some cyclooctane-based pyrazines and quinoxalines. Part 2

Expected Values of Some Molecular Descriptors in Random Cyclooctane Chains

The expected values and limiting behaviours for the Gutman index, Schultz index, multiplicative degree-Kirchhoff index and additive degree-kirchhoff index of a random cyclooctane chain

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