Synthesis of some new 2-substituted-4-sulfamoylphenylazo-thiophene and/or thiazole derivatives as antibacterial agents

Fadda, Ahmed A.; El-badraw, Afnan M.; Refat, Hala M.; Abdel‐Latif, Ehab

doi:10.1080/10426507.2015.1100183

Cited by 11 publications

(10 citation statements)

References 12 publications

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“…The synthesized compounds ( Fig. 66) presented good activities with respect to the Ampicillin against B. subtilis, S. aureus, P. aeruginosa, and E. coli [57].…”

Section: September 2018mentioning

confidence: 98%

“…By heterocyclization of the thiocarbamoyl derivatives with different halogenated reagents, Fadda et al . synthesized 2‐substituted‐4‐sulfamoylphenylazo‐thiophene and thiazole derivatives for investigating the effect of sulfanilamides on the antibacterial activity of thiophene and thiazole derivatives . The synthesized compounds (Fig.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thiophene Scaffold as Prospective Antimicrobial Agent: A Review

Mishra

Sachan

Kumar

et al. 2018

Journal of Heterocyclic Chem

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Thiophene has emerged as a potent scaffold that has pulled the keen interest of the researchers because of its considerable diversity in biological activities. The versatility of the thiophene nucleus is demonstrated by the successful introduction of its derivatives, which have anti‐inflammatory (Thenaldine), anticancer (Ralitrexed), antioxidant (Erdosteine), and antimicrobial (Cefoxitin and Temocillin) activities. This decent variety in the biological response profile has pulled in the consideration of numerous researchers to research this skeleton to its distinctive potential against several activities. This review is integral to prior reviews and plans to review the work regarding antibacterial and antifungal activities of thiophene, substituted thiophene and thiophene‐like compounds, and also Schiff bases of thiophene and substituted thiophenes from year 1995 to the beginning of 2018.

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“…The synthesized compounds ( Fig. 66) presented good activities with respect to the Ampicillin against B. subtilis, S. aureus, P. aeruginosa, and E. coli [57].…”

Section: September 2018mentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Thiophene Scaffold as Prospective Antimicrobial Agent: A Review

Mishra

Sachan

Kumar

et al. 2018

Journal of Heterocyclic Chem

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“…6B) that showed excellent results against S. aureus and C. albicans bacterial strains. Similarly, sulfamoylphenylazo-thiophene and/or thiazole derivatives showed moderate antibacterial activity [77]. Besides compounds with sulpha group(s), the antimicrobial activity of other compounds containing azo group has been investigated through in vitro, in vivo, and in silico studies [78,79].…”

Section: Antimicrobial and Antiviral Propertiesmentioning

confidence: 99%

Biomedical Applications of Aromatic Azo Compounds

Ali

Hamid

Rashid

2018

MRMC

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Azo dyes are widely used in textile, fiber, cosmetic, leather, paint and printing industries. Besides their characteristic coloring function, azo compounds are reported as antibacterial, antiviral, antifungal and cytotoxic agents. They have the ability to be used as drug carriers, either by acting as a 'cargo' that entrap therapeutic agents or by prodrug approach. The drug is released by internal or external stimuli in the region of interest, as observed in colon-targeted drug delivery. Besides drug-like and drug carrier properties, a number of azo dyes are used in cellular staining to visualize cellular components and metabolic processes. However, the biological significance of azo compounds, especially in cancer chemotherapy, is still in its infancy. This may be linked to early findings that declared azo compounds as one of the possible causes of cancer and mutagenesis. Currently, researchers are screening the aromatic azo compounds for their potential biomedical use, including cancer diagnosis and therapy. In this review, we highlight the medical applications of azo compounds, particularly related to cancer research. The biomedical significance of cis-trans interchange and negative implications of azo compounds are also discussed in brief.

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“…Depending on the significant pharmacological interests mainly antioxidant activity of substituted thiophenes, there is a strong inspiration for the continuous synthesis of new heterocyclic systems incorporating substituted thiophene moiety. Therefore, further continuation of our previous work, [ 30–34 ] we are informing here the synthesis of some more analogs of various heterocyclic systems (namely; imidazo‐thiazole, imidazo‐tetrazole, imidazo‐triazole, imidazo‐pyridine, imidazo‐imidazole, thiazole and/or thiophene) incorporating 2‐thienyl moiety and evaluating their in vitro anti‐oxidant activity.…”

Section: Introductionmentioning

confidence: 96%

Synthesis of new heterocycles festooned with thiophene and evaluating their antioxidant activity

Abed

Hammouda

Ismail

et al. 2020

Journal of Heterocyclic Chem

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The chemical performance of 5-bromo-2-(bromoacetyl)-thiophene (1) was tested toward the reaction with numerous bi-nucleophilic reagents (namely; 2-aminobenzothiazoles, 2-aminothiazole, 2-aminotetrazole, 2-aminotriazole, 2-aminopyridines, 2-aminobenzimidazole and o-phenylenediamine). Therefore, a series of bridged nitrogen heterocycles bearing thiophene moiety 3, 5, 7, 9, 11, 13 and 15, respectively was synthesized. In addition, the reaction of 5-bromo-2-(bromoacetyl)-thiophene with the thiocarbamoyl compounds 17, 19 and/or 24 afforded the corresponding thienyl-thiazoles 18 or dithien-2-yl ketones 20 and 25, based on the reaction conditions. Treatment of 1 with 2-mercapto-4,6-dimethylnicotinonitrile was achieved to obtain the target dithien-2-yl ketone 28. The new synthesized scaffolds were examined for their antioxidant activity by means of ABTS antioxidant assay. The thienyl-thiazole scaffold 18c and 2-((2-[thiophen-2-yl]-2-oxoethyl)thio)nicotinonitrile derivative 27 displayed a reasonable radical scavenging activity.

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Synthesis of some new 2-substituted-4-sulfamoylphenylazo-thiophene and/or thiazole derivatives as antibacterial agents

Cited by 11 publications

References 12 publications

Thiophene Scaffold as Prospective Antimicrobial Agent: A Review

Thiophene Scaffold as Prospective Antimicrobial Agent: A Review

Biomedical Applications of Aromatic Azo Compounds

Synthesis of new heterocycles festooned with thiophene and evaluating their antioxidant activity

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