Synthesis of Some New Biologically Active Sulfur Compounds Containing Pyrazolo[3,4-d] pyrimidine Moiety

Synthesis and Kinetic Testing of Tetrahydropyrimidine‐2‐thione and Pyrrole Derivatives as Inhibitors of the Metallo‐β‐lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

“…On the other hand, diazotization of 7a-c using sodium nitrite in a mixture of acetic acid and concentrated HCl (2:1) at 0-5°C afforded the carboxamide derivatives 10a-c. This was unexpected, as there are many reports (31)(32)(33)(34)(35)(36)(37) that diazotization of compounds similar to 7 gives the corresponding triazine derivatives (9). The formation of compounds 10 can be explained by the hydrolysis of the cyano group in acidic medium into the amide without formation of the unstable diazonium salt from the amino group.…”

Synthesis of New Pyrroles of Potential Anti‐Inflammatory Activity

“…Alkylation [25][26][27] of pyrrolopyrimidin-2-thiones 6 with halo compounds gave the corresponding S-alkylated pyrimidine derivatives 7. The reaction [28,29] of S-alkylated compounds 7 with hydrazine hydrate yielded the 2-hydrazine derivative 8.…”

Synthesis and Biological Activity of Alkyl (Z) 2-[3-Methyl-2-(methylimino)-4-oxo-1,3-thiazolan-5-yliden]acetates

“…The protozoan cells including Amoeba, Paramecium, Vorticella, Eupletes, and Euglena were cultivated on plant infusion media for Downloaded by [Northeastern University] at 12:33 18 November 2014 11,12 Then, the stock concentrations of 5a-b were prepared. Therefore, anti-protozoan activities of thiazolans (5a-b) were tested by various concentrations of them as following: (1) The prepared culture contains various protozoans such as Euplots; (2) the 500 µl of culture solution was added into a microtube.…”