Synthesis of Some New Unsymmetrical 1,4-Dihydropyridine Derivatives as Potent Antitubercular Agents

Gaveriya, Harsukh; Desai, Bhavik; Vora, Vipul; Shah, Anamik

doi:10.1515/hc.2001.7.2.167

Cited by 12 publications

(13 citation statements)

References 5 publications

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“…The 1,4-dihydropyridines recently been shown to possess anti-TB activity. Dihydropyridine derivative 33 was found to be most potent showing 87% inhibition respectively at a concentration of 12.5μg/mL (Gaveriya et al, 2001). While, presence of imidazole group at 4-position and amide group at 3,5-position (34) increased the activity up to 1 μg/mL against Mtb.…”

Section: Quinolonesmentioning

confidence: 96%

Anti-tubercular activity of some six membered heterocycle compounds

Asif¹

2019

Preprint

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The effectiveness in TB treatment is difficult because the structural composition of the mycobacterial cell wall is very complicated, which makes many drugs ineffective. Tuberculosis is still one of the most imperative infectious disease worldwide becouse its important reason is drug resistant, persistent or latent tuberculosis and synergism with HIV. Furthermore no any new chemical entity has come. The recently application of modern drug design promise to bring significant development in the fight against TB. In present review we discussed brief introduction of tuberculosis.

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Section: Quinolonesmentioning

confidence: 96%

Anti-tubercular activity of some six membered heterocycle compounds

Asif¹

2019

Preprint

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“…For background to the pharmaceutical applications of 1,4-dihydropyridine derivatives, see: Gaveriya et al (2001); Shah et al (2000Shah et al ( , 2002; Marchalin et al (2004); Chhillar et al (2006).…”

Section: Related Literaturementioning

confidence: 99%

Diisopropyl 1-(4-methoxyphenyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Kapoor¹,

Gupta²,

Kant³

et al. 2011

Acta Cryst E

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In the title compound, C28H32N2O7, the 1,4-dihydropyridine ring adopts a flattened boat conformation. The two benzene rings are approximately perpendicular to the dihydropyridine ring, forming dihedral angles of 84.29 (9) and 82.96 (9)° with the mean plane of the 1,4-dihydropyridine unit, whereas the ester groups are only slightly twisted relative to this plane, with dihedral angles of 10.6 (1) and 9.0 (1)°.

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“…Since the early 1980's the presence of a DHP ring in the structure of 1,4-DHP derivatives has been regarded as a prerequisite for calcium (Ca +2 ) channel modulating properties [3]. So 1,4-DHPs classes of compounds are excellent starting synthons for the development of antitubercular agents [4][5][6]. As a result, newly synthesized generations of 1,4-DHPs possess different pharmacological activities such as anticancer [7], antidiabetic [8], antianginal [9], bronchodilating [10], neurotropic [11], antiallergic [12], anti-inflammatory [13], acaricidal, insecticidal, bactericidal, herbicidal [14] and other pharmacological activities [15].…”

Section: Introductionmentioning

confidence: 99%

Rapid synthesis and biological evaluation of 1,4-dihydropyridine derivatives containing a benzothiazolyl moiety

Mithlesh

Pareek

Kant³

et al. 2010

Open Chemistry

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Abstract:A series of N-(6-methylbenzothiazolyl)-2,3,5,6-tetrasubstituted-4-(aryl)-1,4-dihydropyridines were synthesized by reaction of 2-amino-6-methylbenzothiazole, aromatic aldehyde and active methylene compound in methanol by conventional, as well as, microwave irradiation (solvent free and solid support) methods. The microwave irradiation technique gives better yield and shorter reaction time. Among solid supported microwave irradiation better yields are obtained in acidic alumina as compared to silica, neutral alumina, and basic alumina. All compounds were tested for antibacterial and antifungal activities and results have been compared with standard drugs. Entomological activities were also tested. The results showed that a change in the substitution pattern in 1,4-dihydropyridine derivatives may cause a marked effect on their antimicrobial activity.

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Synthesis of Some New Unsymmetrical 1,4-Dihydropyridine Derivatives as Potent Antitubercular Agents

Cited by 12 publications

References 5 publications

Anti-tubercular activity of some six membered heterocycle compounds

Anti-tubercular activity of some six membered heterocycle compounds

Diisopropyl 1-(4-methoxyphenyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Rapid synthesis and biological evaluation of 1,4-dihydropyridine derivatives containing a benzothiazolyl moiety

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