Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity

Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents

“…This condition is characterized by neuronal hyperexcitability and firing [160,161]. Antiepileptic drug (AED) therapy continues to be the mainstay for treatment of epilepsy [162]. Even with the advances in development of AEDs, approximately 20-30% of patients suffer from recurrent seizures [163].…”

Crystal structure of 1-(2H-1,3-benzodioxol-5-yl)-3-(1H-imidazol-1-yl)propan-1-one, C13H12N2O3

“…Their current importance is testified by their ubiquitousness in the fields of medicinal chemistry, material science and agrochemicals [1]. Imidazole-based compounds exhibit diverse biological activities anticancer [2][3][4][5] antibacterial [6,7], antitubercular [8,9], antifungal [10,11], antiviral [12][13][14], anticonvulsant [15][16][17] and antiparkinson's agents [18,19]. The [20][21][22].…”

Environmentally Benign Synthesis of Tetra-Substituted Imidazoles through 4-Components Strategy Mediated by (<I>S</I>)-3-Methyl-1, 1-Diphenylbutane-1, 2-Diamine

“…Importantly imidazole core units have myriad pharmacological impacts and play an important role in different biochemical processes. Modern research has revealed that, highly substituted imidazole derivatives possess a good photo-physical properties and are extensively used as antimicrobial [1], antimalarial [2], anticancer [3], antitumor [4], antibacterial [5], antifungal [6], antidepressant [7], antipyretic [8], anti-inflammatory [9] and antioxidant agents [10]. Because of the importance of imidazoles, there is a continued strong demand for new methods of construction of these heterocycles.…”