Synthesis of Some Novel Arylazo Disperse Dyes Derived from 5-Amino-tetrazolo[1,5-a]pyrimidin-7-ol as Coupling Component and Investigation of Their Absorption Spectra

Abstract

5‐amino‐tetrazolo[1,5‐a]pyrimidin‐7‐ol (I) was synthesized by reaction of 5‐amino‐tetrazole with ethyl cyanoacetate in excellent yield. A series of novel 5‐amino‐6‐arylazotetrazolo[1,5‐a]pyrimidin‐7‐ol dyes were prepared by linking o‐, m‐, p‐anisidine, o‐, m‐, p‐chloroaniline, o‐, m‐, p‐nitroaniline, o‐, m‐, p‐toluidine and aniline to 5‐amino‐tetrazolo[1,5‐a]pyrimidin‐7‐ol (I). The structure of these dyes were confirmed by UV‐vis, FTIR and 1H NMR spectroscopic techniques and elemental analysis. The effect of varying pH and solvent upon the absorption ability of 5‐amino‐6‐arylazotetrazolo[1,5‐a]pyrimidin‐7‐ol sudstituted with electron‐withdrawing and electron‐donating groups at their o‐, m‐, p‐position was examined.

Synthesis of Neoring 6-Methylimidazo[1,2-d][1,2,3,4]thiatriazole-5-carboxylic Acid Derivatives

“…这些研究中，CDC25B 在肿瘤组织中的表达水平超过 正常组织中的 2~3 倍 [3,4] 。 人们在寻找高效合理的抗肿 瘤药物时，发现咪唑并杂环化合物具有较好的抗肿瘤 活性 [5][6][7][8][9] 。为了进一步拓宽寻找抗肿瘤药物的思路，近 年来我们也报道了一系列类似化合物的合成和性质 [10][11][12][13][14][15][16][17][18][19]…”