Synthesis of Some Novel Pyrazole‐Substituted 9‐Anilinoacridine Derivatives and Evaluation for their Antioxidant and Cytotoxic Activities

Abstract

This article focuses on the synthesis of new series of pyrazole‐substituted 9‐anilinoacridine derivatives 5a–m and 6a–l. The compounds were confirmed by physical and analytical data. The synthesized compounds when screened for in vitro antioxidant activity showed promising activity for many compounds. The selected compounds were screened for cytotoxic activity showed promising inhibition of HEp‐2 cell line for the compounds 6c, 6e, and 6f.

Corrosion Inhibition Studies on Mild Steel in Acidic Media with 2-Hydroxy-4ʹ-methoxy Chalcone

“…Chalcones were prepared by condensation of acetophenone with aromatic aldehydes in presence ofsuitable condensing agent 8,9 . They undergo a variety of chemical reactions that leads to many heterocyclic compounds [10][11][12][13] .…”

Molecular Docking studies and in-silico ADMET Screening of Some novel Oxazine substituted 9-Anilinoacridines as Topoisomerase II Inhibitors

“…The intercalative property was referred to the planar aromatic system of the acridine moiety. In the same context, acridines have gained strong ground for various biological activities like antimicrobial, 1 antioxidant, 2 anticancer, [3][4][5] antimalarial, 6 analgesic, 7 antileishmanial, 8 antinociceptive, 9 acetyl cholinesterase inhibitors 10 and antiherpes 11 etc. Amsacrine is the best known compound of 9-anilinoacridines series.…”

An efficient approach to the synthesis of some novel heterocycles related to indoline moiety using [BMIm]Cl catalysis

“…In particular, they are used as antibacterial, antifungal, antiviral, antiphrastic and insecticidal agents [17][18][19][20][21][22][23]. Upon these salient aspects, incorporation of the two pharmacophoric, pyrazole and oxindole, motiffing into a single molecule via efficient and environmentally benign synthetic methods would be beneficial [24].…”