2017
DOI: 10.17344/acsi.2016.2986
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Synthesis of Some Unique Carbamate Derivatives bearing 2-Furoyl-1-piperazine as Valuable Therapeutic Agents

Abstract: The aim of the research work was to synthesize different biologically active carbamate derivatives bearing 2-furoyl-1-piperazine and having modest toxicity. The synthesis was completed as a multiple sequence. The structural confirmation of all the synthesized compounds was obtained by EI-MS, IR and 1 H-NMR spectral data. The enzyme inhibition and antibacterial potential of the synthesized compounds was evaluated. To find the utility of the prepared compounds as possible therapeutic agents their cytotoxicity wa… Show more

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Cited by 6 publications
(2 citation statements)
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“…In agriculture sulfonamides have antiherbicidal and antifungal uses. They have wide applications as antiobesity, 9 anticancer, antiviral, 3 protease inhibitors, 10 diuretic, 11,12 hypoglycemic, 13 antithyroid, 14 antitumor, [15][16][17] anti-neuropathic pain, 18 antibacterial, 19,20 cyclooxygenase 21 and carbonic anhydrase inhibitory agents. 22 Compounds containing a 1,4-benzodioxane skeleton display wider range of biological activities, 23 such as anticancer, 24,25 immunosuppressive, 26 antiinflammatory, 27 antibacterial 28 and some others.…”
Section: Introductionmentioning
confidence: 99%
“…In agriculture sulfonamides have antiherbicidal and antifungal uses. They have wide applications as antiobesity, 9 anticancer, antiviral, 3 protease inhibitors, 10 diuretic, 11,12 hypoglycemic, 13 antithyroid, 14 antitumor, [15][16][17] anti-neuropathic pain, 18 antibacterial, 19,20 cyclooxygenase 21 and carbonic anhydrase inhibitory agents. 22 Compounds containing a 1,4-benzodioxane skeleton display wider range of biological activities, 23 such as anticancer, 24,25 immunosuppressive, 26 antiinflammatory, 27 antibacterial 28 and some others.…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, organic functionalized groups, possessing a specific response interacting with heavy metal ions, have become a new strategy to improve the sensitivity and selectivity for the electrochemical heavy metal sensors. Piperazine (NH) is a six-member heterocyclic compound containing two nitrogen atoms at position 1 and 4 in the ring, which has the strong tendency to coordinate with Hg(II) [11]. Thus, the introduction of NH on graphene would be a good choice to meet the needs of improving the sensitivity and selectivity of an electrochemical sensor towards Hg(II).…”
Section: Introductionmentioning
confidence: 99%