Synthesis of Steroidal Spiro-1′,2′,4′-triazolidine-3′-thiones

Shamsuzzaman, _; Salim, Anwar; Aslam, Mohammad; Naqvi, Fehmida

doi:10.1080/00397919708006825

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General Methods For the Synthesis Of Steroidal Thiosemicarbaz2

Synthesis Of 124-triazole-3-thiones1

Introduction1

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2020

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Cited by 21 publications

(7 citation statements)

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“…The known steroidal thiosemicarbazones (4-6) were synthesized by a literature method [22] which involves the refluxing of an equimolar solution of steroidal ketones (1-3) and thiosemicarbazide in ethanol in the presence of few drops of HCl for 5 h. After cooling, the compounds were filtered and purified by recrystallization from methanol.…”

Section: General Methods For the Synthesis Of Steroidal Thiosemicarbazmentioning

confidence: 99%

Steroidal pyrimidines: Synthesis, characterization, molecular docking studies with DNA and in vitro cytotoxicity

Shamsuzzaman

Dar

Yaseen

et al. 2013

Journal of Molecular Structure

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Section: General Methods For the Synthesis Of Steroidal Thiosemicarbazmentioning

confidence: 99%

Steroidal pyrimidines: Synthesis, characterization, molecular docking studies with DNA and in vitro cytotoxicity

Shamsuzzaman

Dar

Yaseen

et al. 2013

Journal of Molecular Structure

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“…Condensation of gonanone derivatives 188a – c with 20 in acidic media gave the corresponding thiosemicarbazones 189a – c . Oxidative cyclization of thiosemicarbazones 189a – c with hydrogen peroxide yielded the corresponding (5 S )-10,13-dimethyl-17-octylhexadecahydrospiro-[cyclopenta[ a ]phenanthrene-6,3′-1,2,4triazolidine]-5′-thiones 190a – c in 66–78% yields ( Scheme 52 ) [ 79 ].…”

Section: Synthesis Of 124-triazole-3-thionesmentioning

confidence: 99%

Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs

et al. 2020

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Mercapto-substituted 1,2,4-triazoles are very interesting compounds as they play an important role in chemopreventive and chemotherapeutic effects on cancer. In recent decades, literature has been enriched with sulfur- and nitrogen-containing heterocycles which are used as a basic nucleus of different heterocyclic compounds with various biological applications in medicine and also occupy a huge part of natural products. Therefore, we shed, herein, more light on the synthesis of this interesting class and its application as a biologically active moiety. They might also be suitable as antiviral and anti-infective drugs.

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“…1±7 These thiadiazolines have also been reported to be biologically active materials. 8±10 Here we report a novel and convenient preparation of some substituted steroidal (6R)-spiro-D 2' -1',3',4'-thiadiazolines in high yields by the acetylation of steroidal 6-ketone thiosemicarbazones 11 with acetic anhydride and pyridine at 80 8 8C. 100% conversion was observed on TLC which also showed formation of a single product.…”

mentioning

confidence: 92%