Acetylation of 5-cholestan-6-one thiosemicarbazone 1, and its 3-acetoxy-2 and 3-chloro-3 analogues with acetic anhydride and pyridine at 80 8 8C afford selectively the corresponding (6R)-spiro-1',3',4'-thiadiazolines 4±6 in high yields.

Synthesis of New Steroidal Oxazoles and Thiazoles. -Some new steroidal oxazoles (III) and thiazoles (V) are synthesized by a simple condensation of steroidal α-bromoketones (I) with urea and thiourea, respectively. -(SHAMSUZZAMAN*; SALIM, A.; AKRAM, M. K.; SALEEM, K.; SIDDIQUI, N.; Indian J. Chem., Sect.

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Oxidative cyclization of 5α‐cholestan‐6‐one thiosemicarbazone (1), its 3β‐chloro (2) and 3β‐acetoxy (3) analogues with active manganese dioxide at room temperature afforded selectively the corresponding (6R)‐spiro‐1',2′,4′‐triazoline‐3′‐thiones 4–6. This synthesis has the advantages of mild reaction conditions, easy handling, easily available reagent and high yields. The products have been characterized by analytical and spectral data.

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