Synthesis of Substituted 1,2,4-Triazoles and 1,3,4-Thiadiazoles

Synthesis of New 1,2,4-Triazole[3,4-b][1,3,4]thiadiazoles Bearing Pyrazole as Potent Antimicrobial Agents

“…Similarly, the absence of signals for the -SH and -NH 2 protons in the 1 H-NMR spectra followed by the presence of aromatic protons in the region of d 7.60 and 7.92 ppm well support the structures. In the 13 C-NMR spectra, the prominent signals corresponding to the carbons of [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazole ring for all the compounds, observed nearly at d 152.1, 144.3 and 134.9 ppm are proof of further evidence of their structures. In summary all the newly synthesized compounds exhibited satisfactory spectral data consistent with their molecular structures.…”

“…12) 1,2,4-Triazole system is also an important starting material in the synthesis of biologically active heterocycles, which constitute an important class of organic compounds with diverse biological activities, including antiparasitic, analgesic, antibacterial and anti-inflammatory activities. [13][14][15][16][17][18] Further, triazole fused with other heterocyclic rings is also found to possess diverse applications in the field of medicine. [19][20][21][22] The commonly known systems are triazolo-pyridines, 19) triazolo-pyridazines, 20) triazolo-pyrimidines, 21) triazolo-pyrazines, 22) triazolo-triazines 21) and triazolo-thiadiazines.…”

Synthesis and Antimicrobial Activity of Bis-[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazin-3-yl)phenyl]methanes and Bis-[(triazolo[3,4-b]thiadiazipin-3-yl)phenyl]methanes

“…11 It is interesting to use 1,2,4-triazole derivatives as precusors in the synthesis of some important biologically active heterocycles, [12][13][14][15] which constitute an important class of organic compounds with diverse biological activities, including antiparasitic, analgesic, antibacterial and anti-inflammatory activities. [16][17][18][19][20][21] In addition, it was reported that triazole fused with a six-membered ring system is also found to possess diverse applications in the field of medicine. [22][23][24][25] The commonly known systems are triazolo-pyridines, 26 triazolo-pyridazines, 27 triazolo-pyrimidines, 28 triazolo-triazines, 29 triazolo-pyrazines, 30 triazolo-triazenes, 31 a few monomeric triazolo-thiadiazine, 31 and triazolo-thiadiazepines, 32 although there are not many triazoles fused to thiadiazines and thiadiazepines, there is a number of them that are incorporated into a wide variety of therapeutically important compounds possessing a broad spectrum of biological activities.…”

Recent Advancements and Biological Activities of Aryl Propionic Acid Derivatives: A Review

“…NSAIDs are widely used for the treatment of different types of arthritis and musculoskeletal disorders [3][4][5][6][7][8] . The biological response of NSAIDs results from the suppression of prostaglandin (PG) biosynthesis in which the cyclooxygenase (COX) enzyme is the key intermediate in the biosynthesis of prostaglandin from arachidonic acid 9,10 .…”