Synthesis of substituted phenols via 1,1-dichloro-2-nitroethene promoted condensation of carbonyl compounds with DMF

Wang, Fukai; Wu, Wei; Xu, Xiaoyong; Shao, Xusheng; Li, Zhong

doi:10.1016/j.tetlet.2018.04.076

Cited by 11 publications

(2 citation statements)

References 24 publications

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“…The insertion of a CH from the NMe 2 of DM under metal-free conditions has been reported for the synthesis of cyclic compounds such as: pyrimidines from t -BuOOH-mediated reaction between acetophenones, amidines and DMF (Equation (15)) [ 47 ], substituted phenols also from three components cycloadditions (Equation (16)) [ 48 ], 3-acylindoles from 2-alkenylanilines (Equation (17)) [ 49 ], benzimidazoles and benzothiazole from o -phenylenediamine or 2-aminobenzenethiol through carbon dioxide-mediated cyclization (Equation (18)) [ 50 ]. …”

Section: Ch Fragmentmentioning

confidence: 99%

Recent Uses of N,N-Dimethylformamide and N,N-Dimethylacetamide as Reagents

Bras

Мuzart

2018

Molecules

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Section: Ch Fragmentmentioning

confidence: 99%

Recent Uses of N,N-Dimethylformamide and N,N-Dimethylacetamide as Reagents

Bras

Мuzart

2018

Molecules

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“…反应是通过硫代酰肼与 DMF 的偶联和环合两个步骤实现的, 提供了一种简单、经济地合成 1,3,4-噻二唑的方法(Scheme 47). 还有其他文献报道了以 DMF 为 CH 源的成环反应[44][45][46][47] , 这些研究为 DMF 作为 CH 源构建环状化合物提供了新的和有效的途径.刘卫兵等[49] 报道以 DMF 为氧源, 实现羰基化合物中 α-C-H 键的羟基化, 成功合成了 α-羟基芳酮, 产率达到 57%～88% (Scheme 49). 也可提供双合成子.…”

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N,N-Dimethylformamide: An Versatile Organic Synthetic Reagent

Diao¹,

Yang²,

Yang³

et al. 2021

Chinese Journal of Organic Chemistry

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The development of simple and efficient strategies for the preparation of various functional molecules from low cost and readily available starting substrates is one of significant goal in the field of synthetic chemistry. N,N-Dimethylformamide (DMF) is not only a common and excellent no-proton polar solvent, but also an important industrial raw material and a multipurpose synthetic reagent. The recent progress in the application of DMF as multifunctional reactant in carbonylation, formylation, ammoniation, carbamoylation as well as carbon source, hydrogen source and oxygen source The paper is reviewed.

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Rhodium(II) Acetate‐Catalysed Cyclization of Pyrazol‐5‐amine and 1,3‐Diketone‐2‐diazo Compounds Using N,N‐Dimethylformamide as a Carbon‐Hydrogen Source: Access to Pyrazolo[3,4‐b]pyridines

Ning

Zuo

et al. 2019

Adv Synth Catal

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Access topyrazolo [3,4-b]pyridines through a rhodium-catalysed intermolecular cyclization of pyrazol-5-amine and cyclic 1,3-diketone-2diazo compounds, has been developed. A methyl carbon of N,N-dimethylformamide (DMF) performed as a carbon-hydrogen source for the construction of the pyridine ring. Various pyrazolo [3,4b]pyridine derivatives were obtained under mild conditions using air as the terminal oxidant.

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Synthesis of substituted phenols via 1,1-dichloro-2-nitroethene promoted condensation of carbonyl compounds with DMF

Cited by 11 publications

References 24 publications

Recent Uses of N,N-Dimethylformamide and N,N-Dimethylacetamide as Reagents

Recent Uses of N,N-Dimethylformamide and N,N-Dimethylacetamide as Reagents

N,N-Dimethylformamide: An Versatile Organic Synthetic Reagent

Rhodium(II) Acetate‐Catalysed Cyclization of Pyrazol‐5‐amine and 1,3‐Diketone‐2‐diazo Compounds Using N,N‐Dimethylformamide as a Carbon‐Hydrogen Source: Access to Pyrazolo[3,4‐b]pyridines

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