Synthesis of Substituted Pyridines Using a,b-Unsaturated Nitriles and Active Cyano Compounds

Preparation of 2,6-Dimethyl-4-arylpyridine- 3,5-dicarbonitrile: A Paired Electrosynthesis

“…The synthesis of polysubstituted pyridines, particularly the 3,5-dicarbonitrile, has received considerable attention due to its chemistry 1 and photochemistry, but also to its antibacterial activity as nifedipine analogue, as intermediate in thrombin inhibition, or its use to avoid the prion replication through structure-based drugs design . On the other hand, polysubstituted 1,4-dihydropyridines are interesting as pharmacologically active substances, antioxidants, and NADH coenzyme analogues that mediate the hydrogen transfer in biological systems …”