Synthesis of succinic acid 12α-deoxoartemisinyl ester 4′-O-demethyl-4β-(4″-nitroanilino)-4-desoxypodophyllotoxin

Yuan, Yonghong; Wei, Dongzhi; Lü, Yanhua; Dou, Yusheng

doi:10.1007/s10600-007-0185-z

Chem Nat Compd

2007

DOI: 10.1007/s10600-007-0185-z

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Synthesis of succinic acid 12α-deoxoartemisinyl ester 4′-O-demethyl-4β-(4″-nitroanilino)-4-desoxypodophyllotoxin

Yonghong Yuan

Dongzhi Wei

Yanhua Lü

et al.

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Cited by 3 publications

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“…To our knowledge, there are no reports on the insecticidal activity and synthesis of dimers of celangulin-V and podophyllotoxin, although some dimeric chemical structures have especially high biological activities in drug research. Examples of identical twin drugs and nonidentical twin drugs include artemisinin [7,8], protein kinase C (PKC) [9], and paclitaxel-camptothecin [10].…”

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Synthesis and insecticidalactivity of novel dimers of celangulin-V and podophyllotoxin

Zhang

et al. 2009

Chem Nat Compd

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Celangulin-V (1) and podophyllotoxin (2) are both natural compounds with significant insecticidal activity. The identical and nonidentical dimers of celangulin-V and podophyllotoxin (3, 4, 5) were synthesized using succinic acid as the linker, and their insecticidal activities against 3rd instar larvae of Mythimna separata were tested. Only the identical dimer of celangulin-V (3) show some insecticidal activity.

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confidence: 99%

Synthesis and insecticidalactivity of novel dimers of celangulin-V and podophyllotoxin

Zhang

et al. 2009

Chem Nat Compd

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Synthesis and biological evaluation of a novel artesunate–podophyllotoxin conjugate as anticancer agent

Zhang

Fan

Zhang

et al. 2016

Bioorganic & Medicinal Chemistry Letters

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Lignopurines: A new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation

Castro

Corral

García

et al. 2012

European Journal of Medicinal Chemistry

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Synthesis of succinic acid 12α-deoxoartemisinyl ester 4′-O-demethyl-4β-(4″-nitroanilino)-4-desoxypodophyllotoxin

Cited by 3 publications

References 11 publications

Synthesis and insecticidalactivity of novel dimers of celangulin-V and podophyllotoxin

Synthesis and insecticidalactivity of novel dimers of celangulin-V and podophyllotoxin

Synthesis and biological evaluation of a novel artesunate–podophyllotoxin conjugate as anticancer agent

Lignopurines: A new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation

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