Synthesis of superabsorbent hydrogel nanocomposites for use as hemostatic agent

Mirzakhanian, Zeinab; Faghihi, Khalil; Barati, Aboulfazl; Momeni, Hamid Reza

doi:10.1080/00914037.2016.1171218

Cited by 11 publications

(8 citation statements)

References 43 publications

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“…Superabsorbent hydrogel nanocomposites (HNCs) were studied as potent hemostats [58]. Three different types of nanocomposites were synthesized: i) SiO2, ii) clinoptilolite (natural zeolite) and iii) Ca 2+ -modified clinoptilolite [58]. Porosity plays a vital role for the swelling capability of HNCs.…”

Section: Organic Hemostats 2311 Hydrogel Based Hemostatsmentioning

confidence: 99%

“…The swelling property decreased in salt solution due to an uneven distribution of ions in the medium and the decrease of the polymer network. This nanocomposite material was applied in a surgically exposed femoral artery of a rat model where hemostasis was achieved rapidly [58]. The underlying hemostasis mechanism is the stimulation of intrinsic pathway of blood coagulation cascade (from the nanoparticles) and the fast swelling of the composite matrix provides physical barrier to form a hemostatic plug [58].…”

Section: Organic Hemostats 2311 Hydrogel Based Hemostatsmentioning

confidence: 99%

“…This nanocomposite material was applied in a surgically exposed femoral artery of a rat model where hemostasis was achieved rapidly [58]. The underlying hemostasis mechanism is the stimulation of intrinsic pathway of blood coagulation cascade (from the nanoparticles) and the fast swelling of the composite matrix provides physical barrier to form a hemostatic plug [58]. The fast swelling of nanoparticles can lead to compression necrosis of tissue [59], which could be a major concern about this potential hemostat.…”

Section: Organic Hemostats 2311 Hydrogel Based Hemostatsmentioning

confidence: 99%

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Preliminary investigation of the potential of mesoporous bioactive glasses to treat hemorrhage

Rahman¹

2021

Preprint

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Hemorrhage is the primary cause of death in both trauma and war. Commercially available hemostats cannot achieve hemostasis within two minutes of application and cannot inhibit bacterial infection, which are the properties of an ideal hemostatic agent. Organic hemostats are acidic in nature and can lead to inflammation. Inorganic hemostats can achieve hemostasis with fewer complications. Mesoporous bioactive glasses (MBGs) are inorganic agents that possess high surface area, pore volume and ordered channel structure. They have the potential to act as molecular sieves for platelets and other serum proteins to aggregate. Calcination heating rate is a major processing parameter during the synthesis of MBGs. Any variation in calcination heating rate could alter the physical properties of MBGs, affecting their ability to facilitate clotting. A low heating rate is preferred because it can yield more ordered mesoporous channel structures. A series of novel MBGs based on the glass composition (80-x) SiO2- 15 CaO- 5 P2O5- x Ta2O5 (mol%) were synthetized using a 1°C/min calcination heating rate. The effect of Ta incorporation on the glass structure was investigated. X-ray diffraction revealed that all glasses were completely amorphous. Fourier transform infrared spectroscopy showed that higher concentrations of Ta (5 and 10 mol%) in the glass structure acted as a network modifier which disrupts the silica backbone and leads to discontinuities in porous channel structures, confirmed by transmission electron microscopy. Brunauer-Emmett-Teller (BET) theory quantified the effects of the discontinuities through surface area measurement. It was found that MBGs with 0 and 0.5 mol% of Ta2O5 in the glass structure had 373.87 and 373.98 m2/g surface area respectively indicating that such low levels of Ta incorporation did not influence surface area. The addition of further Ta in the glass structure reduced surface area and produced more discontinuities in the channel structure. 1, 5 and 10 mol% Ta had approximately 5, 12 and 20% reduced surface area compared to 0 mol% Ta in the glass structure. The whole blood coagulation study indicated that MBGs with lower concentrations of Ta (0 and 0.5 mol%) could achieve 58% and 46% hemostatic efficiency, which decreased as tantalum content increased. It is concluded that the application of a low heating rate during calcination, of the order of 1°C/min, is more likely to result in mesoporous bioactive glasses with high surface area and pore volume than MBG samples processed at a higher heating rate. MBGs containing 0 and 0.5 mol% Ta could be potential hemostatic agent.

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Section: Organic Hemostats 2311 Hydrogel Based Hemostatsmentioning

confidence: 99%

Section: Organic Hemostats 2311 Hydrogel Based Hemostatsmentioning

confidence: 99%

Section: Organic Hemostats 2311 Hydrogel Based Hemostatsmentioning

confidence: 99%

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Preliminary investigation of the potential of mesoporous bioactive glasses to treat hemorrhage

Rahman¹

2021

Preprint

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“…However, the clot strength in the mouse model was poor and the tissue-adhesive properties needed to be improved so that the hydrogel isn't washed away before sufficient clotting occurred. In work performed by Mirzakhanian et al, nanoparticles of silica and zeolites were embedded into acrylic-starch hydrogels (separately) to activate the intrinsic pathways of coagulation while concentrating coagulation factors [51]. Using a femoral artery rat model, they showed that the hydrogel nanocomposite (HNC) arrested the bleeding and the rat survived post-operatively for at least seven days.…”

Section: Hydrogel Based Hemostatsmentioning

confidence: 99%

The Potential of Tantalum-Doped Mesoporous Bioactive Glasses for Hemostasis

Mendonca¹

2021

Preprint

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Synthesis and characterization of the first mesoporous bioactive glasses (MBGs) containing tantalum (Ta) are reported, alongside their potential as hemostats. A series of silica MBGs with the molar composition of (80-x)% Si, 15% Ca, 5% P and x% Ta, with x = 0 to 10, were synthesized by the sol-gel method. Increasing Ta content from 1 to 10 mol% caused a decrease in the surface area and pore volume of ~20% and ~35%, respectively, due to the increase in non-bridging oxygens and mismatch of thermal expansion coefficient which creates discontinuities in the ordered channel structure. However, the effect is not significant on the amount of ions released from the samples into deionized water, for short durations (<60 min). In a mouse tail cut model, a significant decrease (≥ 50%) in average bleeding time was found for Ta-MBGs compared to controls (commercial hemostat Arista® and a Ta-free MBG). There was no significance in hemolytic activity between plain blood and when MBG is present and cytotoxicity results show that increasing Ta content from 0 to 10% reduced MBG toxicity by more than 15%; this effect was visually confirmed by live/dead cell assays. Further studies are proposed to determine the mechanism of Ta involvement with the hemostatic process.

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“…Natural or synthetic zeolites are microporous crystalline solids with well-defined structures, showing biocompatibility, nontoxicity, large surface areas, and high pore volumes. All these properties render natural zeolites suitable for the biomedical field as controlled release systems [13][14][15] and haemostatic agents [16]. Sotoudeh et al [17] have obtained nanocomposite hydrogels based on polyethylene glycol, polyacrylic acid, and polyacrylamide with zeolite NPs, which were tested in terms of the controlled release of drugs.…”

Section: Introductionmentioning

confidence: 99%

Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery

et al. 2020

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This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.

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Synthesis of superabsorbent hydrogel nanocomposites for use as hemostatic agent

Cited by 11 publications

References 43 publications

Preliminary investigation of the potential of mesoporous bioactive glasses to treat hemorrhage

Preliminary investigation of the potential of mesoporous bioactive glasses to treat hemorrhage

The Potential of Tantalum-Doped Mesoporous Bioactive Glasses for Hemostasis

Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery

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