The body can't control massive bleeding without treatment. Different hemostatic agents have been prepared recently, but most of them are ineffective in severe bleeding and expensive or cause safety concerns. In this study, in order to achieve fast control of bleeding, we synthesized and characterized fast-swelling porous superabsorbent hydrogel (FSPSH) and investigated its use as a hemostatic agent. The FSPSH was prepared by grafting acrylic acid and acrylamide onto starch through free-radical polymerization in aqueous solution. The FSPSH was characterized by Fourier transform infrared, X-ray diffraction, field emission scanning electron microscope, and thermogravimetric analysis. Then, temporal swelling behavior and coagulation time experiments were used to predict the in vivo behavior of the FSPSH. The hemocompatibility of synthesized FSPSH was evaluated by hemolysis test and blood cells function. In vivo study using femoral artery injury in rat demonstrated the FSPSH's ability to aid in rapid hemostasis. Furthermore, monitoring the rat on first and seventh day after femoral artery injury also showed no harmful effect. This study indicates that FSPSH adsorbs fluid and swells, thus forms a physical barrier to blood loss. FSPSH, moreover, as hemostat is simple to use, lightweight, stable, and harmless.

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In this work, a series of antibacterial poly(ether-amide)/silver nanocomposites (PANCs) was prepared via in situ preparation of Ag nanoparticles within a new poly(ether-amide) (PA) matrix. A new type of dicarboxylic acid (DA) containing ether and aliphatic moieties was successfully synthesized via a solvent-free reaction. Then a new PA with high solubility in common organic solvents was synthesized from a direct reaction of 4,4-diamino diphenylmethane and the DA. Silver nanoparticles were embedded within the PA chains through using a silver/ammonia complex [Ag(NH 3 ) 2 ] + . The formation of nano silver was confirmed by X-ray diffraction, transmission electron microscopy, and UV-vis spectroscopy. The effect of Ag nanoparticles on thermal properties of the prepared nanocomposites was studied by the thermogravimetric analysis. The results showed that the thermal properties of the nanocomposites were improved as compared with the neat PA. The antibacterial capability of the PANCs was studied by the disk diffusion method against Escherichia coli, which suggested that the PANCs can be considered as good antibacterial agents. C 2016 Wiley Periodicals, Inc. Adv Polym Technol 201 , , 21669; View this article online at wileyonlinelibrary.com.

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