Synthesis of supramolecular biodendrimeric β-CD-(spacer-β-CD)<sub>21</sub><i>via</i>click reaction and evaluation of its application as anticancer drug delivery agent

Toomari, Yousef; Namazi, Hassan

doi:10.1080/00914037.2015.1129960

Cited by 23 publications

(2 citation statements)

References 43 publications

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“…In vitro release study of L-ascorbic acid from the titania particles was conducted by using a dialysis bag method (Wang et al. 2008;Hanson 1982;Toomari and Namazi, 2016;Lasoń et al, 2016;Huang et al, 2017;Stebbins et al, 2017;Wei et al, 2010;Tanabe et al, 1988) in phosphate buffer saline as release media. A photostability test was conducted on the sample to investigate whether the effect of inhibiting degradation of L-ascorbic acid could be obtained by encapsulating L-ascorbic acid into the titania hollow particles.…”

Section: Release Properties Of Vitamins From Tio 2 Porous Hollow Partmentioning

confidence: 99%

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

Kadota

Shirakawa

2021

KONA

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Advanced functional materials require sophisticated control of particle characteristics. The bottom-up process has been extensively used to produce functional materials for controlling the particle properties of composite particles. We propose crystallization at liquid-liquid interfaces as an advanced particle formation method. This review introduces crystallization at a liquid-liquid interface based on several case studies used in various applications. Conventional crystallization has been generally used to produce crystals and particles with homogeneous particle properties. Liquid-liquid interfacial crystallization makes it possible to create composite particles with hetero-phase structures and interfaces. Liquid-liquid interfacial crystallization with an inkjet technique can control the droplet size accurately, and the shape and particle size distribution are successfully controlled in inorganic-organic composite particles. In addition, we succeed in creating organic-organic composite particles using the interfacial crystallization by an ultrasonic spray nozzle. The coating efficiency of organic particles on the particles is enhanced using the ultrasonic spray nozzle in comparison with anti-solvent crystallization. In this study, the fabrication of inorganic-organic composite particles using a coaxial tube reactor on the liquid-liquid interfacial crystallization is proven successful. These findings suggest that liquid-liquid interfacial crystallization is a promising means of efficiently producing composite particles because of their applicability to infusion in various processes.

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Section: Release Properties Of Vitamins From Tio 2 Porous Hollow Partmentioning

confidence: 99%

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

Kadota

Shirakawa

2021

KONA

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“…As another example of the application of anticancer drug delivery agent, it could be referred to bio-dendrimeric β-CD-(spacer-β-CD) supramolecule which was synthesized through click reaction. 30 …”

Section: Introductionmentioning

confidence: 99%

Drug nanocarrier agents based on starch-g-amino acids

Namazi¹,

Abdollahzadeh²

2017

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Introduction: In the recent decades, starch has been modified using different methods for the various forms of applications. Some new starch derivatives were prepared through a simple and convenient method in the grafting of amino acids: L-alanine, L-leucine and L-phenyl alanine to starch. Methods: First, the amine groups of amino acids were protected using phthalic anhydride then the acidic side of amino acids were activated with chlorination using thionyl chloride, and the resultant acid chlorides were reacted with starch in aqueous media at room temperature. Results: Performing the various spectroscopy experiments on the obtained compounds showed that the new derivative of starch has been formed. The structure of all synthesized materials was determined and confirmed using common spectroscopy methods and their thermal behavior was examined using DSC experiment. Conclusion: New amino acid derivatives of starch and their nanocarriers successfully prepared through a simple and convenient method. The size of nanocarriers evaluated using DLS and TEM experiments. The spherical shape of particles shows that nanocarriers have been formed and the size of these particles are approximately 92, 137 and 97 nm. Performing the wettability test determined that all the resulted materials are soluble in water. Nanocarriers of the obtained modified starches were prepared using dialysis method and naproxen was utilized as a model drug molecule. The drug release dynamics in buffered solution were studied and investigation of the drug release mechanism showed that in case of L-alanine- and L-phenylalanine-modified starches, drug release followed the Fickian diffusion with a slight deviation.

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β‐Cyclodextrin PAMAM Dendrimer: How to Overcome the Tumbling Process for Getting Fully Available Host Cavities

et al. 2020

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The synthesis of a G0 polyamidoamide (PAMAM) dendrimer end‐capped with four β‐cyclodextrin (β‐CD) units, named as Tetra‐CD was performed by using copper(I)‐catalyzed alkyne‐azide cycloaddition (CuAAC). This new platform presents a considerable high water‐solubility in comparison to native β‐CD. Tumbling process involving half of the CD cavities in D2O was evidenced by 1H NMR spectroscopy. Interaction of adamantane with Tetra‐CD has been fully investigated by 1D/2D NMR techniques and mass spectrometry besides a joint study on new β‐CD monomers (named as A and B) and on a dimer (Di‐CD) and a trimer (Tri‐CD). The obtained results demonstrate that the tumbling effect can be shifted in the presence of an appropriate hydrophobic guest resulting in the full host‐ability of the CD units in water for that guest.

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Synthesis of supramolecular biodendrimeric β-CD-(spacer-β-CD)₂₁viaclick reaction and evaluation of its application as anticancer drug delivery agent

Cited by 23 publications

References 43 publications

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

Drug nanocarrier agents based on starch-g-amino acids

β‐Cyclodextrin PAMAM Dendrimer: How to Overcome the Tumbling Process for Getting Fully Available Host Cavities

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Synthesis of supramolecular biodendrimeric β-CD-(spacer-β-CD)21viaclick reaction and evaluation of its application as anticancer drug delivery agent

Cited by 23 publications

References 43 publications

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

Drug nanocarrier agents based on starch-g-amino acids

β‐Cyclodextrin PAMAM Dendrimer: How to Overcome the Tumbling Process for Getting Fully Available Host Cavities

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Product

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Synthesis of supramolecular biodendrimeric β-CD-(spacer-β-CD)₂₁viaclick reaction and evaluation of its application as anticancer drug delivery agent